Evidence Library

PubMed-anchored ingredient dossiers

62 evidence cards · 6 main anchors + 56 sub-source ingredients · each citing primary literature (PubMed PMID) and surfacing authorized claims verbatim across FDA · EFSA · ANVISA jurisdictions.

Six Main Anchors

ASXAN flagship ingredient families · first-class evidence dossiers.

  • Tier A

    Astaxanthin (Haematococcus pluvialis natural)

    51 PMID anchor SKIN · VISION · CARDIO

    View dossier →
  • Tier C

    Fucoxanthin (Brown-algae xanthophyll)

    55 PMID anchor ENDO · METABOLISM · LIVER

    View dossier →
  • Tier C

    Yeast Protein (S. cerevisiae whole-cell protein isolate)

    11 PMID anchor MUSCLE · METABOLISM · IMMUNE

    View dossier →
  • Tier A

    Omega-3 (EPA/DHA/ALA)

    102 PMID anchor CARDIO · CNS · IMMUNE

    View dossier →
  • Tier A

    Vitamin D3 (Cholecalciferol)

    26 PMID anchor MUSCULO · IMMUNE · ENDO

    View dossier →
  • Tier A

    NMN (β-Nicotinamide Mononucleotide)

    13 PMID anchor MITO · METABOLISM · CNS

    View dossier →

Sub-source ingredients (56)

Cluster sub-sources across NAD+ family, lipid sources, carotenoid family, vitamin family, and functional sub-ingredients · each with PubMed citation chain.

  • A

    Whey Protein (WPC · WPI · WPH · Native)

    39 PMID MUSCULO · METABOLISM

    Dossier →
  • B

    NADH (Reduced Nicotinamide Adenine Dinucleotide)

    1 PMID MITO · CNS

    Dossier →
  • A

    Carotenoids (family · 8 core compounds)

    97 PMID VISION · SKIN

    Dossier →
  • A

    Fish Oil (EPA + DHA · marine)

    32 PMID CARDIO · CNS

    Dossier →
  • A

    Beta-Glucan (β-glucan · cereal + yeast variants)

    31 PMID CARDIO · IMMUNE

    Dossier →
  • A

    Protein (cluster T0 hub · whey/casein/soy/pea/plant/yeast)

    78 PMID MUSCULO · METABOLISM

    Dossier →
  • B

    Collagen Peptides (Hydrolyzed Type I/II/III)

    28 PMID SKIN · MUSCULO

    Dossier →
  • A

    CoQ10 (Ubiquinone / Ubiquinol)

    42 PMID CARDIO · MITO

    Dossier →
  • A

    Lutein (Marigold-derived xanthophyll)

    38 PMID VISION · CNS

    Dossier →
  • A

    Zeaxanthin (Marigold/algal-derived xanthophyll)

    29 PMID VISION · CNS

    Dossier →
  • A

    Magnesium (glycinate · citrate · L-threonate · oxide)

    45 PMID CNS · MUSCULO

    Dossier →
  • A

    Creatine Monohydrate

    67 PMID MUSCULO · METABOLISM

    Dossier →
  • B

    Curcumin (Curcuma longa · turmeric polyphenol)

    51 PMID IMMUNE · MUSCULO

    Dossier →
  • B

    Berberine (Berberis alkaloid)

    36 PMID METABOLISM · ENDO

    Dossier →
  • B

    L-Theanine (γ-glutamylethylamide · tea-derived amino acid)

    24 PMID CNS · IMMUNE

    Dossier →
  • A

    NR (Nicotinamide Riboside · Niagen)

    24 PMID MITO · METABOLISM

    Dossier →
  • C

    Niacinamide (Nicotinamide · Vitamin B3 amide form)

    2 PMID SKIN · METABOLISM

    Dossier →
  • C

    Niacin (Nicotinic Acid · Vitamin B3 acid form)

    2 PMID METABOLISM · CARDIO

    Dossier →
  • C

    L-Tryptophan

    2 PMID CNS · METABOLISM

    Dossier →
  • C

    NADPH (Reduced NAD Phosphate)

    0 PMID MITO · METABOLISM

    Dossier →
  • C

    NMNH (Reduced β-NMN · Reduced Nicotinamide Mononucleotide)

    1 PMID MITO · METABOLISM

    Dossier →
  • B

    Casein (Micellar · Calcium Caseinate · Sodium Caseinate · Hydrolysate)

    2 PMID MUSCULO · METABOLISM

    Dossier →
  • B

    Soy Protein (SPC · SPI · Textured Soy Protein)

    2 PMID MUSCULO · CARDIO

    Dossier →
  • B

    Pea Protein (Yellow Split Pea Isolate · Concentrate)

    2 PMID MUSCULO · METABOLISM

    Dossier →
  • B

    Plant Protein Blend (Pea + Rice + Hemp + Soy combinations)

    2 PMID MUSCULO · METABOLISM

    Dossier →
  • B

    Rice Protein (Brown Rice Protein Isolate)

    1 PMID MUSCULO · METABOLISM

    Dossier →
  • C

    Hemp Protein (Cannabis sativa Seed Protein)

    1 PMID MUSCULO · METABOLISM

    Dossier →
  • B

    Vitamin E · Tocopherols (α-Tocopherol family)

    1 PMID CELL · VISION

    Dossier →
  • B

    Tocotrienols (Palm Tocotrienol-Rich Fraction · Annatto-Sourced)

    1 PMID CELL · CARDIO

    Dossier →
  • B

    Vitamin K2 · Menaquinone (MK-4 · MK-7)

    2 PMID MUSCULOSKELETAL · CARDIO

    Dossier →
  • A

    Vitamin B12 · Cobalamin (Cyanocobalamin · Methylcobalamin · Hydroxocobalamin · Adenosylcobalamin)

    1 PMID BLOOD · NEURO

    Dossier →
  • A

    Folate · Vitamin B9 (Folic Acid · 5-MTHF)

    2 PMID BLOOD · REPRODUCTIVE

    Dossier →
  • B

    Daily Multivitamin / Multi-Mineral Formula

    1 PMID BLOOD · METABOLISM

    Dossier →
  • B

    β-Carotene (Provitamin A · Mixed Carotene)

    1 PMID VISION · SKIN

    Dossier →
  • C

    Lycopene (Tomato Carotenoid)

    1 PMID CELL

    Dossier →
  • A

    Algal Oil (Microalgae-Sourced DHA · EPA · DHA blends)

    1 PMID CARDIO · NEURO

    Dossier →
  • B

    Krill Oil (Phospholipid-Esterified Omega-3 · Astaxanthin co-content)

    1 PMID CARDIO · CELL

    Dossier →
  • B

    Flaxseed ALA (Plant Omega-3 · Linum usitatissimum)

    1 PMID CARDIO · METABOLISM

    Dossier →
  • B

    Cod Liver Oil (Vitamin A · D · EPA · DHA combined)

    1 PMID CARDIO · BONE

    Dossier →
  • A

    EPA (Eicosapentaenoic Acid · Pure / High-EPA Formulations)

    1 PMID CARDIO · CELL

    Dossier →
  • A

    DHA (Docosahexaenoic Acid · Pure / High-DHA Formulations)

    1 PMID NEURO · VISION

    Dossier →
  • B

    Alpha-Lipoic Acid (Thioctic Acid · R-ALA · Racemic ALA)

    1 PMID NEURO · METABOLISM

    Dossier →
  • B

    Acetyl-L-Carnitine (ALC · ALCAR)

    1 PMID NEURO · METABOLISM

    Dossier →
  • A

    Zinc

    2 PMID IMMUNITY · SKIN

    Dossier →
  • A

    Iron

    2 PMID BLOOD · CARDIO

    Dossier →
  • A

    Calcium

    2 PMID MUSCULOSKELETAL · MUSCULO

    Dossier →
  • A

    Iodine

    2 PMID ENDO · NEURO

    Dossier →
  • A

    Copper

    2 PMID BLOOD · NEURO

    Dossier →
  • B

    Chromium

    2 PMID ENDO · CARDIO

    Dossier →
  • A

    Vitamin C

    2 PMID METABOLISM

    Dossier →
  • A

    Selenium

    3 PMID IMMUNE · ENDO

    Dossier →
  • A

    Vitamin A

    5 PMID SKIN · VISION

    Dossier →
  • A

    Vitamin B6

    3 PMID ENDO · CNS

    Dossier →
  • C

    Molybdenum

    3 PMID METABOLISM

    Dossier →
  • A

    Phosphorus

    3 PMID METABOLISM · MUSCULO

    Dossier →
  • B

    Manganese

    2 PMID METABOLISM · MUSCULO

    Dossier →

What Tier A · B · C mean

Every evidence card carries a tier badge that summarizes the strength of the underlying source-linked literature and regulatory recognition.

Tier A · Strong

Three or more randomized controlled trials or meta-analyses in major peer-reviewed journals, plus multi-market authorized health claims (FDA SSA or qualified, EFSA Reg 432/2012, ANVISA IN 28/2018).

Tier B · Moderate

One or two randomized controlled trials, supported by consistent observational and mechanistic evidence. Authorized claims may be limited to a single market or framed as educational reference.

Tier C · Emerging

Mechanistic depth or single small-cohort signals. Larger replication is pending. Claims surface as educational reference only. Authorized regulatory claims are absent or narrowly scoped.

Deep dives · long-form evidence articles

Historical RCT reviews · head-to-head ingredient decision trees · 25-year evidence sweeps.

Browse 6 deep-dive evidence articles →

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