🇺🇸 FDA
NOT GRAS · not approved as dietary supplement ingredient (no NDIN filed)
NADPH (Reduced NAD Phosphate)
Also known as: β-NADPH · NADP-H · Reduced Nicotinamide Adenine Dinucleotide Phosphate
Mechanism of action
- Anabolic reductive biosynthesis cofactor
- GSH reductase substrate
- NOX enzyme substrate
- Lipid biosynthesis cofactor
Molecular + tissue targets
- NADPH pool (cytosolic + mitochondrial)
- Glutathione recycling
- Fatty acid biosynthesis
Dosage range
No established human dosing · supplement market 10-30 mg/day (unsupported by human RCT)
Safety notes
NO human RCT data · safety profile unknown for oral supplementation · biology suggests stability + bioavailability limited
Cross-market regulatory status
🇪🇺 EFSA
Novel Food likely required · no current authorization
🇧🇷 ANVISA
IN 28/2018 GE (general element) case-by-case registration required
Common use cases
- antioxidant support (preclinical-dominant · 0 human RCT)
- biosynthetic cofactor (mechanism-based)
Cross-reference
Health goals: longevity stack
Full dossier: /ingredients/nadph/
Machine-readable JSON: /api/nc/nadph.json