{
  "slug": "nadph",
  "name": "NADPH (Reduced NAD Phosphate)",
  "alternate_names": [
    "β-NADPH",
    "NADP-H",
    "Reduced Nicotinamide Adenine Dinucleotide Phosphate"
  ],
  "mechanism": [
    "Anabolic reductive biosynthesis cofactor",
    "GSH reductase substrate",
    "NOX enzyme substrate",
    "Lipid biosynthesis cofactor"
  ],
  "target": [
    "NADPH pool (cytosolic + mitochondrial)",
    "Glutathione recycling",
    "Fatty acid biosynthesis"
  ],
  "use_case": [
    "antioxidant support (preclinical-dominant · 0 human RCT)",
    "biosynthetic cofactor (mechanism-based)"
  ],
  "body_system": [
    "MITO",
    "METABOLISM"
  ],
  "evidence_tier": "C",
  "evidence_anchor_pmid_count": 0,
  "dosage_range": "No established human dosing · supplement market 10-30 mg/day (unsupported by human RCT)",
  "safety_notes": "NO human RCT data · safety profile unknown for oral supplementation · biology suggests stability + bioavailability limited",
  "regulatory": {
    "fda": "NOT GRAS · not approved as dietary supplement ingredient (no NDIN filed)",
    "efsa": "Novel Food likely required · no current authorization",
    "anvisa": "IN 28/2018 GE (general element) case-by-case registration required"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/nadph/",
  "related_goal_slugs": [
    "longevity-stack"
  ],
  "related_lifestyle_slugs": [],
  "last_evidence_review": "2026-06-02",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-02",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}