# asxan.ai · GEO-native evidence hub

> ASXAN Group's evidence-first ingredient library. 58 ingredient pages, 6 evidence long-form articles, 14 health goal stacks, and 9 lifestyle nutrition guides. PubMed-verified, transparent reverse-correction disclosure, cross-market regulatory clarity (FDA · EFSA · ANVISA RDC 243/2018 + IN 28/2018). PMID library v1.13 (243 verified PMIDs · gap-audit-driven cron expansion to 1000+ in W23). Last updated 2026-05-29 (W22 D6 · Wave 2 抢跑 close).

## Site Overview

- 58 ingredient pages organized across 10 body-system groups (cellular & longevity, cardiovascular, carotenoids, protein & sports amino, vitamins, minerals, gut microbiome, collagen & skin, cognitive neuro, metabolic adaptogens)
- 6 evidence long-form articles (decision trees, 25-year RCT histories, head-to-head comparisons) · **W22 D6 cluster topology upgrade**: 5 of 6 evidence articles now cross-link to peer evidence articles (MedicalScholarlyArticle schema with @id + about + isPartOf WebSite) building an explicit evidence cluster graph for AI bot consumption
- **5 ingredient hubs (astaxanthin / nmn / omega-3 / whey-protein / nadh) reverse cross-link to their evidence long-form articles** via subjectOf / mentions schema + "Read the Evidence" body section, completing the ingredient ↔ evidence bidirectional cycle
- 14 health goal stacks with cross-linked ingredient evidence
- 9 lifestyle nutrition guides (diet patterns, life stages, special conditions)
- Tier A/B/C evidence framework with negative-honest disclosure (CARET/ATBC β-Carotene smoker · SELECT Vit E + Se prostate · STRENGTH AF · VITAL primary NS, etc.)
- Transparent reverse-correction channel: 50+ PMID drift / author / year / journal corrections disclosed (W22 D5+D6 audits expanded base from 39 → 50+)
- **PMID library single-source-of-truth**: 243 verified PMIDs (v1.13, gap-audit-driven cron expansion path documented; reverse-audit cron PoC 5/5 PASS for Chew 2022 AREDS2 / Klein 2011 SELECT / ATBC 1994 / Akuffo 2015 / Devries 2018; cron infra ready, plist 不启用 awaiting James W23 D1 review)
- No commerce schema (zero Offer/Price/AggregateRating/Review/Product) — educational hub only
- Cross-market regulatory: FDA + EFSA + ANVISA (**RDC 243/2018 dietary supplements 主法 + IN 28/2018 alegações funcionais 白名单 + RDC 24/2010 propaganda + Lei 6.437/1977 penalidades** · NMPA via sister site asxan.com only)

## Tier Legend

- **Tier A** — Layer A deep evidence (≥ 15 PMID, RCT-anchored, mechanism + clinical + safety + regulatory complete)
- **Tier B** — Intermediate evidence (5-15 PMID or in build)
- **Tier C / Stub** — Placeholder (0 PMID), evidence-first content build pending Wave 2

## Hubs

- [Home](https://asxan.ai/)
- [About](https://asxan.ai/about/)
- [Science](https://asxan.ai/science/)
- [Ingredients (58)](https://asxan.ai/ingredients/)
- [Blog (6)](https://asxan.ai/blog/)
- [Goals (14)](https://asxan.ai/goals/)
- [Lifestyles (9)](https://asxan.ai/lifestyles/)
- [FAQ](https://asxan.ai/faq/)

## Ingredients (58 · Evidence-First Library)

### Cellular & longevity (10 pages)

- [NAD+ cluster hub](https://asxan.ai/ingredients/nad-cluster/): Tier A · Cluster T0 · NMN/NR/NAD+/NMNH/NADH 5-form comparison · NAD biosynthesis · CD38 decline · SLC12A8 transporter controversy honest framing (Grozio 2019 vs Schmidt-Brenner 2020 + Yamamoto 2022 reframe) · 20 PMID · 11 FAQ · lastUpdated 2026-05-26
- [NMN](https://asxan.ai/ingredients/nmn/): Tier A · 13+ human RCT · Pencina KM 2023 MIB-626 (PMID 36740954) · Yoshino 2021 prediabetic women (PMID 33888596) · Kim 2022 sleep (PMID 35215405) · Zhang J 2025 meta (PMID 39116016) · Song Q 2023 antiaging update (PMID 37619764) · Katayoshi 2023 arterial stiffness (PMID 36797393) · 56 PMID · 10 FAQ · lastUpdated 2026-05-26
- [NAD+ direct](https://asxan.ai/ingredients/nad-plus/): Tier A · oral/IV NAD+ direct supplementation · 0 large RCT honest disclosure · 99% market = NR/NMN/NADH alternatives · 42 PMID · 10 FAQ · lastUpdated 2026-05-26
- [NMNH (reduced NMN)](https://asxan.ai/ingredients/nmnh/): Tier A · Tier C emerging strict control · 0 human RCT · in vitro + mouse evidence only · "better than NMN" framing tightened · MedicalGuideline severity=LowConfidence · 32 PMID · 10 FAQ · lastUpdated 2026-05-26
- [NADH (reduced NAD)](https://asxan.ai/ingredients/nadh/): Tier A · Tier B human evidence · Forsyth LM 1999 CFS anchor RCT (PMID 10071523) · Castro-Marrero 2015 NADH+CoQ10 (PMID 25386668) · Nadlinger 2002 ATP ex vivo (PMID 12399028) · 54 PMID · 10 FAQ · lastUpdated 2026-05-26
- [Spermidine](https://asxan.ai/ingredients/spermidine/): Stub · evidence-first content build pending · related goal: longevity-stack · see page
- [Urolithin A](https://asxan.ai/ingredients/urolithin-a/): Stub · evidence-first content build pending · related goal: longevity-stack · see page
- [Resveratrol](https://asxan.ai/ingredients/resveratrol/): Stub · evidence-first content build pending · related goal: longevity-stack · see page
- [PQQ (Pyrroloquinoline Quinone)](https://asxan.ai/ingredients/pqq/): Stub · evidence-first content build pending · related goal: cognitive-support · see page
- [CoQ10 (Ubiquinone)](https://asxan.ai/ingredients/coq10/): Stub · evidence-first content build pending · related goal: heart-health · see page

### Cardiovascular (5 pages)

- [Omega-3 hub](https://asxan.ai/ingredients/omega-3/): Tier A · Cluster T0 family hub · EPA/DHA/ALA mechanism · SPMs biosynthesis · membrane phospholipid integration · PPAR-α · GPR120 · arachidonic competition · 4 sub-source deep cross-links · 66 PMID · lastUpdated 2026-05-24
- [Fish Oil](https://asxan.ai/ingredients/fish-oil/): Tier A · cardiovascular hard-endpoint RCT · GISSI-Prevenzione · STRENGTH · REDUCE-IT · EPA vs DHA · oxidation markers · honest negative trials · 32 PMID · lastUpdated 2026-05-24
- [Algal Omega-3](https://asxan.ai/ingredients/algal-oil/): Tier A · DHA dominance · pregnancy DOMInO trial · plant-based nutrition · sustainable source · cognitive evidence · 28 PMID · lastUpdated 2026-05-24
- [Krill Oil](https://asxan.ai/ingredients/krill-oil/): Tier A · phospholipid omega-3 · choline bonus · Antarctic krill MSC fishery first-certified 2010 · bioavailability vs fish oil head-to-head RCT (Schuchardt 2011 PMID 21854650 vs Ulven 2011) · 29 PMID · lastUpdated 2026-05-24
- [Flaxseed-ALA](https://asxan.ai/ingredients/flaxseed-ala/): Tier A · ALA plant precursor · ALA→EPA→DHA conversion ~5-15% · cardiovascular meta · lignans secondary · Bassett/Rodriguez-Leyva/Pierce 2009 PMID 19568181 (not Cardoso Carraro 2012 · audit-fixed) · 23 PMID · lastUpdated 2026-05-24

### Carotenoids (7 pages)

- [Carotenoids hub](https://asxan.ai/ingredients/carotenoids/): Tier A · Cluster T0 educational hub · 8 core carotenoid compounds overview (α/β-carotene · lutein · zeaxanthin · lycopene · astaxanthin · β-cryptoxanthin · fucoxanthin) · biosynthesis · absorption · BCO1 SNP · CARET/ATBC/AREDS2/SELECT cluster-wide negative-honest framework · 97 PMID · lastUpdated 2026-05-24
- [Astaxanthin](https://asxan.ai/ingredients/astaxanthin/): Tier A · cardiovascular HDL · skin moisture/elasticity · PCOS reproductive markers · fatigue · exercise · ASXAN platform module (Haematococcus pluvialis >15% global market share natural producer) · 58 PMID · lastUpdated 2026-05-24
- [Beta-Carotene](https://asxan.ai/ingredients/beta-carotene/): Tier A · smoker page-level callout ×4 (NIH-ODS/MedlinePlus paradigm) · ATBC 1994 lung cancer +18% · CARET 1996 +28% · AREDS1→AREDS2 paradigm transition · BCO1 SNP 12:1 RAE pro-vitamin A honest · 62 PMID + MedicalGuideline schema ×4 · lastUpdated 2026-05-24
- [Lutein](https://asxan.ai/ingredients/lutein/): Tier A · AREDS2 primary NS + lowest L+Z quartile -26% · macular pigment optical density · blue light biophysical fact vs digital eye strain Tier B/C strict layering · CARES cognition · 57 PMID · lastUpdated 2026-05-24
- [Zeaxanthin](https://asxan.ai/ingredients/zeaxanthin/): Tier A · macular pair with lutein · meso-zeaxanthin foveal center · CREST (PMID 24621122 + 27367585) vs MOST AMD (PMID 25976647) strict distinction exemplar · Bone 2007 MPOD trial · 67 PMID · lastUpdated 2026-05-24
- [Lycopene](https://asxan.ai/ingredients/lycopene/): Tier A · prostate health 5-layer evidence stratification (obs Tier B / RCT Tier C / FDA 2005 "very limited credible evidence") · SELECT NOT-lycopene callout (PMID 21990298 = vitamin E + selenium) · cardiovascular SBP -5.66 mmHg biomarker · cis/trans isomers · 60 PMID · lastUpdated 2026-05-24
- [Fucoxanthin](https://asxan.ai/ingredients/fucoxanthin/): Tier A · brown algae marine xanthophyll · metabolic syndrome adjunct · weight management · UCP1 thermogenesis mechanism · clinical evidence map · 21 PMID · lastUpdated 2026-05-23

### Protein & sports amino (9 pages)

- [Protein hub](https://asxan.ai/ingredients/protein/): Tier A · Cluster T0 family hub · DIAAS framework · mTORC1/leucine/MPS · incretin response · TEF · 6 sub-source deep cross-links · GLP-1 evidence-stage honest disclosure · 78 PMID · lastUpdated 2026-05-24
- [Whey Protein](https://asxan.ai/ingredients/whey-protein/): Tier A · rapid digestion · leucine 11% · sports nutrition · GLP-1 incretin · A1/A2 supplementary · 39 PMID · lastUpdated 2026-05-24
- [Casein Protein](https://asxan.ai/ingredients/casein-protein/): Tier A · slow-digesting · Boirie pre-sleep MPS trial · sustained amino acid release · 41 PMID · lastUpdated 2026-05-24
- [Soy Protein](https://asxan.ai/ingredients/soy-protein/): Tier A · DIAAS 0.84-0.91 · 3-RCT male hormone rebuttal meta (Hamilton-Reeves 2010 PMID 19524224) · cardiovascular adjunct · 35 PMID · lastUpdated 2026-05-24
- [Pea Protein](https://asxan.ai/ingredients/pea-protein/): Tier A · plant-forward sports nutrition · 3 methodological caveats honest · DIAAS limitation · 20 PMID · lastUpdated 2026-05-24
- [Plant Protein](https://asxan.ai/ingredients/plant-protein/): Tier A · blend ≠ single plant clear framing · ESG balanced · DIAAS combinatorial · 30 PMID · lastUpdated 2026-05-24
- [Yeast Protein](https://asxan.ai/ingredients/yeast-protein/): Tier A · NMPA precautionary framework · 3-tier evidence layering · mycoprotein academic alias · 25 PMID · lastUpdated 2026-05-24
- [BCAA (Branched-Chain Amino Acids)](https://asxan.ai/ingredients/bcaa/): Stub · evidence-first content build pending · related goal: athletic-performance · see page
- [Creatine](https://asxan.ai/ingredients/creatine/): Stub · evidence-first content build pending · related goal: athletic-performance · see page

### Vitamins (10 pages)

- [Vitamin D3](https://asxan.ai/ingredients/vitamin-d3/): Tier A · VITAL primary NS · skeletal/extra-skeletal pleiotropy · cross-market FDA/EFSA/ANVISA · 25(OH)D thresholds honest framing · 37 PMID · lastUpdated 2026-05-23
- [Vitamin E hub](https://asxan.ai/ingredients/vitamin-e/): Tier A · Cluster T0 family hub · 8 vitamers (α/β/γ/δ tocopherol + tocotrienol) · α-TTP selectivity · SELECT trial prostate +17% honest negative · EFSA 2024 UL lowered 1000→300 mg/day · 64 PMID · lastUpdated 2026-05-24
- [Tocopherols](https://asxan.ai/ingredients/tocopherols/): Tier A · natural d-α-tocopherol vs synthetic dl-α-tocopherol · 5-CV negative cluster (HOPE PMID 10639540 / HOPE-TOO PMID 15769967 / PHS II PMID 18997197 / WHS / SELECT) · 25 PMID · lastUpdated 2026-05-24
- [Tocotrienols](https://asxan.ai/ingredients/tocotrienols/): Tier A · α-tocopherol interference · 3-source decision tree (palm/annatto/rice bran) · Rafique 2024 SR honest · U-shape dose-response · 41 PMID · lastUpdated 2026-05-24
- [Vitamin K2 (Menaquinone)](https://asxan.ai/ingredients/vitamin-k2/): Stub · evidence-first content build pending · related goal: heart-health, joint-bone · see page
- [Vitamin B12](https://asxan.ai/ingredients/b12/): Stub · evidence-first content build pending · related lifestyle: senior-60-plus, plant-based · see page
- [Biotin (Vitamin B7)](https://asxan.ai/ingredients/biotin/): Stub · evidence-first content build pending · related goal: hair-nail · see page
- [Folate (Vitamin B9)](https://asxan.ai/ingredients/folate/): Stub · evidence-first content build pending · related lifestyle: pregnancy · see page
- [Multivitamin](https://asxan.ai/ingredients/multivitamin/): Stub · evidence-first content build pending · related lifestyle: glp-1-companion · see page
- [Choline](https://asxan.ai/ingredients/choline/): Stub · evidence-first content build pending · related lifestyle: pregnancy · see page

### Minerals (2 pages)

- [Iron](https://asxan.ai/ingredients/iron/): Stub · evidence-first content build pending · related lifestyles: pregnancy, plant-based · see page
- [Magnesium](https://asxan.ai/ingredients/magnesium/): Stub · evidence-first content build pending · related lifestyles: keto, high-stress, menopause, athletic-performance · see page

### Gut microbiome (4 pages)

- [Beta-Glucan](https://asxan.ai/ingredients/beta-glucan/): Tier A · 2 types strict distinction (cereal vs yeast) · cereal cholesterol lowering FDA + EFSA + ANVISA triple authorization · yeast immune AHCC/HPV emerging · Ibrügger 2013 negative honest · 31 PMID + 2 regulatory citations · lastUpdated 2026-05-24
- [Akkermansia muciniphila](https://asxan.ai/ingredients/akkermansia/): Stub · evidence-first content build pending · related goal: gut-digestion · see page
- [Probiotics](https://asxan.ai/ingredients/probiotics/): Stub · evidence-first content build pending · related goal: gut-digestion · see page
- [Berberine](https://asxan.ai/ingredients/berberine/): Stub · evidence-first content build pending · related goal: gut-digestion, weight-management · see page

### Collagen & skin (3 pages)

- [Collagen Peptides](https://asxan.ai/ingredients/collagen-peptides/): Stub · evidence-first content build pending · related goal: skin-beauty · see page
- [Type II Collagen](https://asxan.ai/ingredients/type-2-collagen/): Stub · evidence-first content build pending · related goal: joint-bone · see page
- [Hyaluronic Acid](https://asxan.ai/ingredients/hyaluronic-acid/): Stub · evidence-first content build pending · related goal: skin-beauty · see page

### Cognitive neuro (4 pages)

- [Phosphatidylserine (PS)](https://asxan.ai/ingredients/phosphatidylserine/): Stub · evidence-first content build pending · related goal: cognitive-support · see page
- [Nervonic Acid](https://asxan.ai/ingredients/nervonic-acid/): Stub · evidence-first content build pending · related goal: cognitive-support · see page
- [L-Theanine](https://asxan.ai/ingredients/l-theanine/): Stub · evidence-first content build pending · related lifestyle: high-stress · see page
- [Ashwagandha](https://asxan.ai/ingredients/ashwagandha/): Stub · evidence-first content build pending · related lifestyle: high-stress · see page

### Metabolic adaptogens (4 pages)

- [MCT (Medium-Chain Triglycerides)](https://asxan.ai/ingredients/mct/): Stub · evidence-first content build pending · related lifestyle: keto · see page
- [Curcumin](https://asxan.ai/ingredients/curcumin/): Stub · evidence-first content build pending · related goal: inflammation-relief · see page
- [Saw Palmetto](https://asxan.ai/ingredients/saw-palmetto/): Stub · evidence-first content build pending · related goals: hair-nail, reproductive-health · see page
- [Soy Isoflavones](https://asxan.ai/ingredients/soy-isoflavones/): Stub · evidence-first content build pending · related goals: menopause-support, lifestyle: menopause · see page

## Evidence Long-form Articles (6 articles · Tier A · W22 D6 peer cluster topology upgrade)

- [Natural vs Synthetic Astaxanthin](https://asxan.ai/blog/natural-vs-synthetic-astaxanthin-evidence-comparison/): Tier A · Haematococcus pluvialis natural carotenoid vs synthetic chemical synthesis · 76 PMID · 11 schema types · 2 reverse correction · **peer evidence cluster cross-link → NAD+ 25-year (mitochondrial / oxidative-stress overlap) + Omega-3 (cardiovascular / lipid overlap)** · ingredient hub reverse link from /ingredients/astaxanthin/ · lastUpdated 2026-05-29
- [Omega-3 25-year CV + EPA Inflammation](https://asxan.ai/blog/omega-3-evidence-history-cardiovascular-and-inflammation/): Tier A · DART (1989) → GISSI → VITAL → REDUCE-IT → STRENGTH RCT history · EPA inflammation + Vascepa Rx visual disclaimer · 67 PMID · 15 schema types · 6 reverse correction · **peer evidence cluster cross-link → Natural vs Synthetic Astaxanthin (shared cardiovascular + lipid-metabolism endpoints)** · ingredient hub reverse link from /ingredients/omega-3/ · lastUpdated 2026-05-29
- [Protein Source Decision Tree (Whey vs Yeast Focus)](https://asxan.ai/blog/protein-source-decision-tree-whey-vs-yeast-focus/): Tier A · 5 form DIAAS framework · whey vs yeast (Quorn mycoprotein) head-to-head · GLP-1 era muscle preservation · 88 PMID · 12 schema types · 5 reverse correction · no peer evidence cross-link (protein cluster standalone) · ingredient hub reverse link from /ingredients/whey-protein/ · lastUpdated 2026-05-29
- [NMN vs NR Decision Tree](https://asxan.ai/blog/nmn-vs-nr-decision-tree-evidence/): Tier A · 5-dimension comparison (absorption / RCT volume / NAD+ rise / cost-regulation / safety) · SLC12A8 controversy framing · 74 PMID · 11 FAQ · 5 reverse correction · **peer evidence cluster cross-link → NAD+ 25-year (historical RCT base) + Reduced NADH vs NMNH (redox-axis adjacent)** · ingredient hub reverse link from /ingredients/nmn/ · lastUpdated 2026-05-29
- [NAD+ 25-year RCT History](https://asxan.ai/blog/nad-25-year-rct-history-evidence/): Tier A · 1999 Forsyth NADH CFS → 2015 Castro-Marrero → 2016 Trammell NR → 2019-2025 Yoshino/Yi/Pencina/Zhang J NMN era · transparent disclosure of PMID drift lessons · 117 PMID · 11 FAQ · 8 reverse correction · **peer evidence cluster cross-link → NMN vs NR (downstream precursor choice) + Reduced NADH vs NMNH (redox-form adjacent)** · ingredient hub reverse link from /ingredients/nmn/ + /ingredients/nadh/ · lastUpdated 2026-05-29
- [Reduced NADH vs NMNH](https://asxan.ai/blog/reduced-nadh-vs-nmnh-evidence/): Tier A · NADH Tier B human RCT vs NMNH Tier C emerging (0 human RCT) · CFS evidence anchor · 99% market = NMN alternative honest disclosure · 48 PMID · 10 FAQ · 4 reverse correction · **peer evidence cluster cross-link → NAD+ 25-year (chronology base) + NMN vs NR (oxidized precursor adjacent)** · ingredient hub reverse link from /ingredients/nadh/ · lastUpdated 2026-05-29

### Peer Evidence Cluster Topology (W22 D6 16:00 PDT cross-link spec v0.3)

The 5-evidence-article cluster forms an explicit topology graph for AI bot consumption:

- **NAD+ axis cluster** (3 articles): NAD+ 25-year ↔ NMN vs NR ↔ Reduced NADH vs NMNH — historical chronology + oxidized precursor decision + redox-form comparison
- **Carotenoid + cardiovascular bridge** (2 articles): Natural vs Synthetic Astaxanthin ↔ Omega-3 evidence history — shared cardiovascular + lipid-metabolism endpoint overlap (Urakaze 2021 + Saeidi 2023 RCTs)
- **Cross-cluster bridge** (1 link): Natural vs Synthetic Astaxanthin → NAD+ 25-year — shared mitochondrial / oxidative-stress mechanism context
- **Standalone**: Protein Source Decision Tree — protein cluster does not bridge to other evidence articles; cluster topology serves the athletic-performance / healthy-aging / GLP-1 companion goal hubs directly

All peer cross-links are bidirectional in `mentions` MedicalScholarlyArticle schema entries with `@id`, `about`, and `isPartOf` WebSite fields, enabling AI crawlers to traverse the cluster topology without relying on link text inference.

### Ingredient ↔ Evidence Bidirectional Cycle (W22 D6 17:00 PDT cross-link spec v0.3 Step 1.3)

5 ingredient hubs reverse-link to their evidence long-form articles, completing the ingredient ↔ evidence bidirectional cycle:

- /ingredients/astaxanthin/ ↔ /blog/natural-vs-synthetic-astaxanthin-evidence-comparison/ (1 evidence)
- /ingredients/nmn/ ↔ /blog/nad-25-year-rct-history-evidence/ + /blog/nmn-vs-nr-decision-tree-evidence/ + /blog/reduced-nadh-vs-nmnh-evidence/ (3 evidence)
- /ingredients/omega-3/ ↔ /blog/omega-3-evidence-history-cardiovascular-and-inflammation/ (1 evidence)
- /ingredients/whey-protein/ ↔ /blog/protein-source-decision-tree-whey-vs-yeast-focus/ (1 evidence)
- /ingredients/nadh/ ↔ /blog/reduced-nadh-vs-nmnh-evidence/ + /blog/nad-25-year-rct-history-evidence/ (2 evidence)

Each ingredient hub uses `subjectOf` (or `mentions` for NAD-axis hubs with multiple evidence) MedicalScholarlyArticle schema entries with `@id` + `about` fields. Body content includes a "Read the Evidence (deep dive long-form)" section before References, enabling both AI crawler schema-graph traversal and human reader navigation.

## Health Goal Stacks (14 goals)

- [Longevity Stack](https://asxan.ai/goals/longevity-stack/): Healthy aging stack · related ingredients: astaxanthin, nmn, spermidine, resveratrol, urolithin-a · lastUpdated 2026-05-26
- [Weight Management](https://asxan.ai/goals/weight-management/): Healthy weight management for metabolic, gut, and body-composition evidence mapping · related ingredients: fucoxanthin, berberine, protein/yeast
- [GLP-1 Companion](https://asxan.ai/goals/glp-1-companion/): Evidence-first nutrition companion for GLP-1 medication users · muscle preservation, protein adequacy, metabolic wellness · related ingredients: protein, bcaa, astaxanthin, omega-3
- [Cognitive Support](https://asxan.ai/goals/cognitive-support/): Brain health stack linking omega-3, carotenoids, and emerging cognitive ingredients · related ingredients: phosphatidylserine, nervonic-acid, omega-3, astaxanthin, pqq
- [Heart Health](https://asxan.ai/goals/heart-health/): Cardiovascular support linking omega-3, carotenoids, and vitamin K pathways · related ingredients: omega-3, coq10, astaxanthin, vitamin-k2
- [Eye Protection](https://asxan.ai/goals/eye-protection/): Vision support for lutein, zeaxanthin, and astaxanthin evidence mapping · related ingredients: lutein, zeaxanthin, astaxanthin
- [Joint Bone](https://asxan.ai/goals/joint-bone/): Joint and bone health linking vitamin D3, vitamin K2, collagen, and carotenoid signals · related ingredients: vitamin-d3, vitamin-k2, type-2-collagen, astaxanthin
- [Skin Beauty](https://asxan.ai/goals/skin-beauty/): Skin beauty linking carotenoids, vitamin E, collagen, and hydration-oriented ingredients · related ingredients: astaxanthin, tocopherols, collagen-peptides, hyaluronic-acid, lycopene
- [Hair Nail](https://asxan.ai/goals/hair-nail/): Hair and nail health linking tocotrienols, biotin, saw palmetto, and antioxidant signals · related ingredients: tocotrienols, saw-palmetto, biotin, astaxanthin
- [Reproductive Health](https://asxan.ai/goals/reproductive-health/): Reproductive wellness linking antioxidant and daily vitality ingredient signals · related ingredients: astaxanthin, tocopherols, saw-palmetto, lycopene
- [Menopause Support](https://asxan.ai/goals/menopause-support/): Menopause wellness linking endocrine, bone, and antioxidant ingredient signals · related ingredients: astaxanthin, vitamin-d3, soy-isoflavones
- [Gut Digestion](https://asxan.ai/goals/gut-digestion/): Gut and digestion linking beta-glucan, microbiome, and metabolic ingredient signals · related ingredients: beta-glucan, akkermansia, probiotics, berberine
- [Athletic Performance](https://asxan.ai/goals/athletic-performance/): Sports nutrition linking protein, creatine, BCAA, and astaxanthin signals · related ingredients: protein/yeast, creatine, bcaa, astaxanthin
- [Inflammation Relief](https://asxan.ai/goals/inflammation-relief/): Daily resilience linking omega-3, curcumin, and astaxanthin mechanism signals · related ingredients: omega-3, curcumin, astaxanthin

## Lifestyle Nutrition (9 lifestyles)

- [Keto](https://asxan.ai/lifestyles/keto/): Keto nutrition gap linking electrolyte, omega-3, vitamin D3, and metabolic support signals · related ingredients: magnesium, omega-3, mct, vitamin-d3
- [Plant Based](https://asxan.ai/lifestyles/plant-based/): Plant-based nutrition linking algal omega-3, vitamin D3, plant protein, and micronutrient gaps · related ingredients: omega-3/algal, vitamin-d3, protein/plant, iron, b12
- [Intermittent Fasting](https://asxan.ai/lifestyles/intermittent-fasting/): Intermittent fasting linking protein timing, mineral planning, and cellular renewal signals · related ingredients: protein, magnesium, spermidine
- [Pregnancy](https://asxan.ai/lifestyles/pregnancy/): Pregnancy nutrition linking DHA, vitamin D3, folate, iron, and life-stage evidence mapping · related ingredients: folate, iron, omega-3/algal, vitamin-d3, choline
- [Menopause](https://asxan.ai/lifestyles/menopause/): Menopause wellness linking endocrine, bone, and daily resilience nutrition signals · related ingredients: soy-isoflavones, vitamin-d3, vitamin-k2, magnesium
- [Senior 60+](https://asxan.ai/lifestyles/senior-60-plus/): Senior nutrition linking protein, vitamin D3, omega-3, B12, and astaxanthin signals · related ingredients: protein, vitamin-d3, omega-3, b12, astaxanthin
- [GLP-1 Companion Lifestyle](https://asxan.ai/lifestyles/glp-1-companion/): Lifestyle nutrition for GLP-1 medication users · evidence-first muscle preservation, protein adequacy, micronutrient review · related ingredients: protein, bcaa, astaxanthin, multivitamin
- [Athletic Performance Lifestyle](https://asxan.ai/lifestyles/athletic-performance/): Athletic performance linking protein, creatine, magnesium, and astaxanthin signals · related ingredients: protein, creatine, magnesium, astaxanthin
- [High Stress](https://asxan.ai/lifestyles/high-stress/): High-stress lifestyle linking autonomic, mood, sleep, and daily resilience nutrition signals · related ingredients: magnesium, ashwagandha, l-theanine

## AI Crawler Notes

- Robots: GPTBot, ClaudeBot, anthropic-ai, PerplexityBot, Google-Extended, CCBot, Bytespider, Applebot-Extended (all explicit allow)
- Sitemap: https://asxan.ai/sitemap-index.xml
- License: Educational hub · Creative Commons recommended for AI excerpting (attribution to asxan.ai)
- Contact: https://asxan.ai/about/
- **AI citation monitoring (case24 北极星指标)**: 24 keyword (12 EN + 12 ZH · core 4 + ingredient 4 + goal 4 each) × 6-week rotation cycle (4 query/week per 8.M2 frequency wall) covering Perplexity / Google AI Overview / ChatGPT / Gemini / Otterly + 国内 6 AI · cron PoC readiness verified W22 D6 17:10 PDT · plist template ready · awaiting W23 D1 /coda-dispatch first real PoC + James review
- **PMID library reverse-audit cron**: gap-audit script v0.1 (244/463 verified = 52.7% coverage · 219 uncovered · top gap clusters vitamin-e + carotenoids) · v0.2 WebFetch verify path PoC 5/5 PASS (Chew 2022 AREDS2 / Klein 2011 SELECT / ATBC 1994 NEJM landmark / Akuffo 2015 AMD / Devries 2018 protein safety) · cron infra ready, plist 不启用 awaiting W23 D1 review · projected 28 PMID/day × 28 days → ~800 PMID library expansion in Wave 2
- **Strategy reversal #4 (ALL IN B2A)**: asxan.ai is a 2B 官网 (Brand-to-AI/Agent served · educational evidence hub · zero commerce) · 2C 独立站 (sister brands NATURALIS / LAST / 爱生行) operate independently and reverse cite signals from asxan.ai are deferred to Wave 3 (B2A2C business model nail Q3 2026). asxan.ai content uses educational framing only · qualified health claims and FDA Structure/Function disclaimers apply only where SKU jump links are embedded · see Compass-Legal compliance spec v1.1 for 2B/2C dual-track standard.

## Editorial Principles

- Evidence-first Tier A/B/C framework with strict Layer A deep evidence anchoring (≥ 15 PMID, RCT-anchored, full mechanism + clinical + safety + regulatory)
- Negative-honest disclosure across cluster pages: CARET 1996 / ATBC 1994 β-Carotene smoker lung cancer +18-28% · SELECT 2008 vitamin E + selenium prostate +17% · STRENGTH 2020 AF · VITAL 2018 primary NS · HOPE/HOPE-TOO/PHS II/WHS 5-CV negative · Ibrügger 2013 cereal β-glucan negative
- **50+ transparent reverse-correction cases** (PMID drift / author / year / journal corrections disclosed inline · W22 D5+D6 audit expansion)
- No commerce schema (zero Offer/Price/AggregateRating/Review/Product) — educational hub only
- Cross-market regulatory: FDA + EFSA + **ANVISA RDC 243/2018 + IN 28/2018** (NMPA via sister site asxan.com only)
- MedicalWebPage + MedicalGuideline schema with severity gradient (HighConfidence/MediumConfidence/LowConfidence)
- ClaimReview schema for reverse-correction transparency
- **W22 D6 Schema cluster topology upgrade (16:00-17:30 PDT)**: 5 evidence long-form articles now expose @id + isPartOf WebSite + peer MedicalScholarlyArticle entries with about + isPartOf fields. 5 ingredient hubs (astaxanthin / nmn / omega-3 / whey-protein / nadh) reverse cross-link to evidence articles via subjectOf or mentions schema entries. The cluster topology graph is explicitly enumerated in this llms.txt under "Peer Evidence Cluster Topology" section to assist AI crawlers in traversal.

## Reverse-Correction Channel (G5 audit)

- Note: 33 ingredient pages currently in stub status (Wave 2 content build pending). These are listed above with "Stub · see page" tags. Stub pages serve as anchor placeholders for cross-linking from Tier A pages, goals, and lifestyles; full evidence content lands in Wave 2.
- Nested page disclosure: `/ingredients/protein/hydrolyzed/` exists as a sub-page (sports nutrition / absorption-oriented build pending) and is referenced from Goal `athletic-performance` and Lifestyle `senior-60-plus`. Not counted in top-level 58 ingredient total.
- Goal/Lifestyle `relatedIngredients` lists may reference stub-state ingredient slugs (e.g. `coq10`, `spermidine`, `urolithin-a`, `resveratrol`, `phosphatidylserine`, `pqq`, `collagen-peptides`, `type-2-collagen`, `hyaluronic-acid`, `vitamin-k2`, `magnesium`, `iron`, `b12`, `folate`, `choline`, `multivitamin`, `mct`, `curcumin`, `saw-palmetto`, `soy-isoflavones`, `berberine`, `akkermansia`, `probiotics`, `bcaa`, `creatine`, `nervonic-acid`, `l-theanine`, `ashwagandha`, `biotin`, `spermidine`). These cross-links remain valid for AI crawler navigation; landing pages display Wave 2 placeholder content.

## Sister Site

- https://asxan.com (Chinese-language sister site · planned reconstruction)
- NMPA-jurisdiction content lives at sister site only; asxan.ai operates under FDA + EFSA + ANVISA frameworks