Tier B

Collagen Peptides (Hydrolyzed Type I/II/III)

Also known as: Hydrolyzed collagen · Collagen hydrolysate · Bioactive collagen peptides (BCP)

28 PMID anchor · SKIN · MUSCULO · CONNECTIVE · Last reviewed 2026-05-29

Mechanism of action

  • Bioactive dipeptide/tripeptide absorption (Pro-Hyp · Hyp-Gly)
  • Dermal fibroblast collagen synthesis stimulation
  • Chondrocyte matrix turnover signaling
  • Glycine + proline + hydroxyproline amino acid supply

Molecular + tissue targets

  • Dermal extracellular matrix
  • Articular cartilage
  • Connective tissue

Dosage range

2.5-10 g/day hydrolyzed collagen peptides; 40 mg/day UC-II undenatured Type II for joint comfort RCTs

Safety notes

Generally well tolerated; bovine/marine/porcine source allergens possible; vegan-incompatible (animal-derived)

Cross-market regulatory status

🇺🇸 FDA

GRAS · DSHEA dietary supplement; structure/function claims permitted

🇪🇺 EFSA

No authorized health claim (collagen-specific claims rejected 2011)

🇧🇷 ANVISA

RDC 243/2018 dietary supplement · IN 28/2018 alegação funcional not authorized for collagen

Common use cases

  • skin elasticity/hydration
  • joint comfort (research context)
  • connective tissue support
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