🇺🇸 FDA
GRAS · authorized nutrient content claim "high in magnesium" (≥20% DV)
Magnesium (glycinate · citrate · L-threonate · oxide)
Also known as: Mg2+ · Magnesium bisglycinate · Magnesium citrate · Magnesium L-threonate · Magnesium oxide
Mechanism of action
- >300 enzymatic cofactor (kinases · ATP-Mg complex)
- NMDA receptor voltage-gating
- GABA-A receptor positive modulation
- Calcium-channel antagonism in vascular smooth muscle
Molecular + tissue targets
- Neuromuscular junction
- Vascular endothelium
- Bone matrix
- Glycemic regulation
Dosage range
RDA 310-420 mg/day; supplemental 200-400 mg/day elemental Mg; UL 350 mg/day from supplements (FNB · diarrhea threshold)
Safety notes
Diarrhea at supplemental > 350 mg/day (oxide/citrate forms · less common with glycinate); renal impairment risk for accumulation; theoretical interaction with bisphosphonates/quinolones (separate 2h)
Cross-market regulatory status
🇪🇺 EFSA
Authorized claims for magnesium contribution to muscle function, nervous system, bone, electrolyte balance
🇧🇷 ANVISA
RDC 243/2018 dietary supplement · IN 28/2018 Anexo V 7 alegações funcionais (formação ossos+dentes · metabolismo energético · metabolismo proteínas/carboidratos/gorduras · equilíbrio eletrolítico · funcionamento muscular · funcionamento neuromuscular · divisão celular) · Anexo III ≥ 63 mg/dia adultos ≥ 19 anos · gestantes 60 mg/dia
Authorized claims · verbatim (17)
Direct quotes from each jurisdiction's framework · never paraphrased · with framework reference and conditions of use.
🇪🇺 EFSA · 10 claims
Reg 432/2012
Magnesium contributes to a reduction of tiredness and fatigue
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium contributes to electrolyte balance
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium contributes to normal energy-yielding metabolism
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium contributes to normal functioning of the nervous system
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium contributes to normal muscle function
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium contributes to normal protein synthesis
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium contributes to normal psychological function
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium contributes to the maintenance of normal bones
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium contributes to the maintenance of normal teeth
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
Reg 432/2012
Magnesium has a role in the process of cell division
Conditions: The claim may be used only for food which is at least a source of magnesium as referred to in the claim SOURCE OF [NAME OF VITAMIN/S] AND/OR [NAME OF MINERAL/S] as listed in the Annex to Regulation (EC) No 1924/2006.
Authorized 2012
🇧🇷 ANVISA · 7 claims
IN 28/2018 Anexo V alegação funcional
O magnésio auxilia na formação de ossos e dentes.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares cuja quantidade de magnésio atenda aos valores mínimos estabelecidos no Anexo III desta Instrução Normativa.
Authorized 2018
IN 28/2018 Anexo V alegação funcional
O magnésio auxilia no metabolismo energético.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares cuja quantidade de magnésio atenda aos valores mínimos estabelecidos no Anexo III desta Instrução Normativa.
Authorized 2018
IN 28/2018 Anexo V alegação funcional
O magnésio auxilia no metabolismo de proteínas, carboidratos e gorduras.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares cuja quantidade de magnésio atenda aos valores mínimos estabelecidos no Anexo III desta Instrução Normativa.
Authorized 2018
IN 28/2018 Anexo V alegação funcional
O magnésio auxilia no equilíbrio dos eletrólitos.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares cuja quantidade de magnésio atenda aos valores mínimos estabelecidos no Anexo III desta Instrução Normativa.
Authorized 2018
IN 28/2018 Anexo V alegação funcional
O magnésio auxilia no funcionamento muscular.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares cuja quantidade de magnésio atenda aos valores mínimos estabelecidos no Anexo III desta Instrução Normativa.
Authorized 2018
IN 28/2018 Anexo V alegação funcional
O magnésio auxilia no funcionamento neuromuscular.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares cuja quantidade de magnésio atenda aos valores mínimos estabelecidos no Anexo III desta Instrução Normativa.
Authorized 2018
IN 28/2018 Anexo V alegação funcional
O magnésio auxilia no processo de divisão celular.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares cuja quantidade de magnésio atenda aos valores mínimos estabelecidos no Anexo III desta Instrução Normativa.
Authorized 2018
Common use cases
- sleep quality (research context)
- muscle cramp relief
- blood pressure support (mild)
- glycemic regulation adjunct
Cross-reference
Health goals: heart health joint bone cognitive support menopause support
Lifestyles: senior 60 plus high stress menopause athletic performance
Full dossier: /ingredients/magnesium/
Machine-readable JSON: /api/nc/magnesium.json