🇺🇸 FDA
GRAS (turmeric · curcumin) · DSHEA dietary supplement; structure/function claims
Curcumin (Curcuma longa · turmeric polyphenol)
Also known as: Diferuloylmethane · Curcuma longa extract · Bioavailable curcumin (Meriva · Theracurmin · Longvida)
Mechanism of action
- NF-κB pathway inhibition
- NRF2/ARE antioxidant response activation
- COX-2 + 5-LOX dual inhibition
- TNF-α + IL-6 suppression
Molecular + tissue targets
- Inflammatory cytokine cascade
- Joint synovial inflammation
- Hepatic NRF2 axis
Dosage range
500-2000 mg/day standardized curcumin (95% curcuminoids); bioavailability-enhanced (Meriva 1000 mg/day · Theracurmin 90-180 mg/day) lower effective dose
Safety notes
Low oral bioavailability (lipid/phospholipid/piperine co-formulation needed); rare hepatotoxicity case reports at high-dose extract (FDA MedWatch · 2023 EFSA opinion); avoid in gallstone obstruction
Cross-market regulatory status
🇪🇺 EFSA
ADI 3 mg/kg bw/day (2010) under re-evaluation 2024; no authorized health claim
🇧🇷 ANVISA
RDC 243/2018 dietary supplement · IN 28/2018 alegação funcional not authorized
Common use cases
- inflammation markers (CRP)
- joint comfort (OA · research context)
- metabolic inflammation adjunct
Cross-reference
Health goals: inflammation relief joint bone heart health longevity stack
Lifestyles: senior 60 plus high stress
Full dossier: /ingredients/curcumin/
Machine-readable JSON: /api/nc/curcumin.json