{
  "slug": "curcumin",
  "name": "Curcumin (Curcuma longa · turmeric polyphenol)",
  "alternate_names": [
    "Diferuloylmethane",
    "Curcuma longa extract",
    "Bioavailable curcumin (Meriva · Theracurmin · Longvida)"
  ],
  "mechanism": [
    "NF-κB pathway inhibition",
    "NRF2/ARE antioxidant response activation",
    "COX-2 + 5-LOX dual inhibition",
    "TNF-α + IL-6 suppression"
  ],
  "target": [
    "Inflammatory cytokine cascade",
    "Joint synovial inflammation",
    "Hepatic NRF2 axis"
  ],
  "use_case": [
    "inflammation markers (CRP)",
    "joint comfort (OA · research context)",
    "metabolic inflammation adjunct"
  ],
  "body_system": [
    "IMMUNE",
    "MUSCULO",
    "METABOLISM",
    "CARDIO"
  ],
  "evidence_tier": "B",
  "evidence_anchor_pmid_count": 51,
  "dosage_range": "500-2000 mg/day standardized curcumin (95% curcuminoids); bioavailability-enhanced (Meriva 1000 mg/day · Theracurmin 90-180 mg/day) lower effective dose",
  "safety_notes": "Low oral bioavailability (lipid/phospholipid/piperine co-formulation needed); rare hepatotoxicity case reports at high-dose extract (FDA MedWatch · 2023 EFSA opinion); avoid in gallstone obstruction",
  "regulatory": {
    "fda": "GRAS (turmeric · curcumin) · DSHEA dietary supplement; structure/function claims",
    "efsa": "ADI 3 mg/kg bw/day (2010) under re-evaluation 2024; no authorized health claim",
    "anvisa": "RDC 243/2018 dietary supplement · IN 28/2018 alegação funcional not authorized"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/curcumin/",
  "related_goal_slugs": [
    "inflammation-relief",
    "joint-bone",
    "heart-health",
    "longevity-stack"
  ],
  "related_lifestyle_slugs": [
    "senior-60-plus",
    "high-stress"
  ],
  "last_evidence_review": "2026-05-29",
  "schema_version": "nc-public-v0.1",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-05-29",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}