Tier A

NR (Nicotinamide Riboside · Niagen)

Also known as: Nicotinamide Riboside · NIAGEN · NR Chloride · NRC · nicotinamide-riboside

24 PMID anchor · MITO · METABOLISM · CNS · CARDIO · Last reviewed 2026-06-02

Read full dossier → Deep-dive article → JSON (nr.json)

Mechanism of action

NAD+ salvage via NRK1/NRK2 kinase phosphorylation
Sirtuin co-substrate
PARP modulation

Molecular + tissue targets

NAD+ pool
NRK1/NRK2 kinases
SIRT1/SIRT3
Mitochondria

Dosage range

300-1000 mg/day (Trammell 2016 PMID 27721479 PK · Martens 2018 PMID 29599478 RCT 1000 mg/day chronic 6 weeks well-tolerated)

Safety notes

No adequate pregnancy/lactation/pediatric data · transient flushing rare · 1000 mg/day chronic 6 weeks well-tolerated in older adults (Martens 2018 PMID 29599478)

Cross-market regulatory status

🇺🇸 FDA

GRAS 2016 (NIAGEN · ChromaDex GRN 635) · NDIN accepted 2015

🇪🇺 EFSA

Novel Food authorized 2019 (Reg 2019/1746 · ChromaDex · max 300 mg/day adults)

🇧🇷 ANVISA

RDC 243/2018 dietary supplement framework · IN 28/2018 no Anexo V claim · constituent permissible

Common use cases

healthy aging
cardiovascular markers
NAD+ decline
cognitive surrogate

Cross-reference

Health goals: longevity stack heart health cognitive support

Lifestyles: senior 60 plus high stress athletic performance

Full dossier: /ingredients/nr/

Machine-readable JSON: /api/nc/nr.json