{
  "slug": "nr",
  "name": "NR (Nicotinamide Riboside · Niagen)",
  "alternate_names": [
    "Nicotinamide Riboside",
    "NIAGEN",
    "NR Chloride",
    "NRC",
    "nicotinamide-riboside"
  ],
  "mechanism": [
    "NAD+ salvage via NRK1/NRK2 kinase phosphorylation",
    "Sirtuin co-substrate",
    "PARP modulation"
  ],
  "target": [
    "NAD+ pool",
    "NRK1/NRK2 kinases",
    "SIRT1/SIRT3",
    "Mitochondria"
  ],
  "use_case": [
    "healthy aging",
    "cardiovascular markers",
    "NAD+ decline",
    "cognitive surrogate"
  ],
  "body_system": [
    "MITO",
    "METABOLISM",
    "CNS",
    "CARDIO"
  ],
  "evidence_tier": "A",
  "evidence_anchor_pmid_count": 24,
  "evidence_long_form_url": "https://asxan.ai/blog/nmn-vs-nr-decision-tree-evidence/",
  "dosage_range": "300-1000 mg/day (Trammell 2016 PMID 27721479 PK · Martens 2018 PMID 29599478 RCT 1000 mg/day chronic 6 weeks well-tolerated)",
  "safety_notes": "No adequate pregnancy/lactation/pediatric data · transient flushing rare · 1000 mg/day chronic 6 weeks well-tolerated in older adults (Martens 2018 PMID 29599478)",
  "regulatory": {
    "fda": "GRAS 2016 (NIAGEN · ChromaDex GRN 635) · NDIN accepted 2015",
    "efsa": "Novel Food authorized 2019 (Reg 2019/1746 · ChromaDex · max 300 mg/day adults)",
    "anvisa": "RDC 243/2018 dietary supplement framework · IN 28/2018 no Anexo V claim · constituent permissible"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/nr/",
  "related_goal_slugs": [
    "longevity-stack",
    "heart-health",
    "cognitive-support"
  ],
  "related_lifestyle_slugs": [
    "senior-60-plus",
    "high-stress",
    "athletic-performance"
  ],
  "last_evidence_review": "2026-06-02",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-02",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}