🇺🇸 FDA
GRAS · food ingredient · DSHEA dietary supplement
Whey Protein (WPC · WPI · WPH · Native)
Also known as: Whey protein concentrate · Whey protein isolate · Whey protein hydrolysate
Mechanism of action
- mTORC1 activation
- Leucine triggering of MPS
- GLP-1/GIP incretin response
- Rapid amino acid delivery
Molecular + tissue targets
- Skeletal muscle protein synthesis
- Incretin axis
- Glycemic regulation
Dosage range
20-40 g/serving (Macnaughton 2016 RCT 40 g optimal whole-body MPS); daily protein target 1.2-1.6 g/kg/day (Morton 2018 meta)
Safety notes
Lactose intolerance in WPC · acid-ash dietary debunked (Fenton 2009) · healthy-kidney rebuttal (Devries 2018 meta)
Cross-market regulatory status
🇪🇺 EFSA
Authorized claim for protein contribution to muscle mass + bone health
🇧🇷 ANVISA
RDC 243/2018 dietary supplement · IN 28/2018 Anexo V alegação funcional verbatim: "As proteínas auxiliam na formação dos músculos e ossos." (Anexo III ≥ 8,4 g/dia adultos ≥ 19 anos · Anexo VII proteína de referência AAE/g)
Authorized claims · verbatim (4)
Direct quotes from each jurisdiction's framework · never paraphrased · with framework reference and conditions of use.
🇪🇺 EFSA · 3 claims
Reg 432/2012
Protein contributes to a growth in muscle mass.
Conditions: Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a "source of protein" — ≥ 12% of energy value provided by protein; "high protein" — ≥ 20% of energy value provided by protein
Authorized 2012
Reg 432/2012
Protein contributes to the maintenance of muscle mass.
Conditions: Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a "source of protein" — ≥ 12% of energy value provided by protein; "high protein" — ≥ 20% of energy value provided by protein
Authorized 2012
Reg 432/2012
Protein contributes to the maintenance of normal bones.
Conditions: Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a "source of protein" — ≥ 12% of energy value provided by protein; "high protein" — ≥ 20% of energy value provided by protein
Authorized 2012
🇧🇷 ANVISA · 1 claim
IN 28/2018 Anexo V alegação funcional
As proteínas auxiliam na formação dos músculos e ossos.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos cuja: a) quantidade de proteína atenda aos valores mínimos do Anexo III (≥ 8,4 g/dia adultos ≥ 19 anos · 7,8 g 9-18 anos · 2,85 g 4-8 anos · NA para 0-3 anos · 10,65 g gestantes/lactantes); b) quantidade de aminoácidos essenciais por grama de proteína atenda aos valores mínimos para a proteína de referência (Anexo VII)
Authorized 2018
Common use cases
- muscle protein synthesis
- sarcopenia prevention
- GLP-1 companion adequacy
- recovery
Cross-reference
Health goals: athletic performance glp 1 companion longevity stack weight management
Lifestyles: athletic performance senior 60 plus glp 1 companion
Full dossier: /ingredients/whey-protein/
Machine-readable JSON: /api/nc/whey-protein.json