🇺🇸 FDA
GRAS for food/supplement protein
Protein (cluster T0 hub · whey/casein/soy/pea/plant/yeast)
Also known as: Dietary protein · Macronutrient protein
Mechanism of action
- mTORC1 activation
- Leucine triggering of MPS
- GLP-1/GIP incretin response
- DIAAS-graded amino acid bioavailability
Molecular + tissue targets
- Skeletal muscle protein synthesis
- Incretin axis
- Satiety hormones
Dosage range
1.2-1.6 g/kg/day protein intake target (Morton 2018 PMID 28698222 meta); 20-40 g/serving optimal MPS (Macnaughton 2016 PMID 27511985)
Safety notes
Healthy-kidney rebuttal (Devries 2018 meta · PMID 30383278); soy isoflavone hormonal effects rebuttal (Hamilton-Reeves 2010); acid-ash bone hypothesis debunked (Fenton 2009)
Cross-market regulatory status
🇪🇺 EFSA
Authorized claim for protein contribution to muscle mass + bone health
🇧🇷 ANVISA
RDC 243/2018 dietary supplement · IN 28/2018 Anexo V alegação funcional verbatim: "As proteínas auxiliam na formação dos músculos e ossos." (Anexo III ≥ 8,4 g/dia adultos ≥ 19 anos · Anexo VII proteína de referência AAE/g)
Authorized claims · verbatim (4)
Direct quotes from each jurisdiction's framework · never paraphrased · with framework reference and conditions of use.
🇪🇺 EFSA · 3 claims
Reg 432/2012
Protein contributes to a growth in muscle mass.
Conditions: Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a "source of protein" — ≥ 12% of energy value provided by protein; "high protein" — ≥ 20% of energy value provided by protein
Authorized 2012
Reg 432/2012
Protein contributes to the maintenance of muscle mass.
Conditions: Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a "source of protein" — ≥ 12% of energy value provided by protein; "high protein" — ≥ 20% of energy value provided by protein
Authorized 2012
Reg 432/2012
Protein contributes to the maintenance of normal bones.
Conditions: Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a "source of protein" — ≥ 12% of energy value provided by protein; "high protein" — ≥ 20% of energy value provided by protein
Authorized 2012
🇧🇷 ANVISA · 1 claim
IN 28/2018 Anexo V alegação funcional
As proteínas auxiliam na formação dos músculos e ossos.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos cuja: a) quantidade de proteína atenda aos valores mínimos do Anexo III (≥ 8,4 g/dia adultos ≥ 19 anos · 7,8 g 9-18 anos · 2,85 g 4-8 anos · NA para 0-3 anos · 10,65 g gestantes/lactantes); b) quantidade de aminoácidos essenciais por grama de proteína atenda aos valores mínimos para a proteína de referência (Anexo VII)
Authorized 2018
Common use cases
- muscle protein synthesis
- sarcopenia prevention
- GLP-1 companion
- weight management
Cross-reference
Health goals: athletic performance glp 1 companion weight management longevity stack
Lifestyles: athletic performance senior 60 plus glp 1 companion plant based
Full dossier: /ingredients/protein/
Machine-readable JSON: /api/nc/protein.json