{
  "authorized_claims": [
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to a growth in muscle mass.",
      "authorization_date": "2012"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to the maintenance of muscle mass.",
      "authorization_date": "2012"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to the maintenance of normal bones.",
      "authorization_date": "2012"
    },
    {
      "market": "ANVISA",
      "framework_reference": "IN 28/2018 alegação funcional",
      "claim_verbatim": "As proteínas auxiliam na formação dos músculos e ossos. Seu consumo deve estar associado a uma alimentação equilibrada e hábitos de vida saudáveis.",
      "authorization_date": "2018"
    }
  ],
  "slug": "protein",
  "name": "Protein (cluster T0 hub · whey/casein/soy/pea/plant/yeast)",
  "alternate_names": [
    "Dietary protein",
    "Macronutrient protein"
  ],
  "mechanism": [
    "mTORC1 activation",
    "Leucine triggering of MPS",
    "GLP-1/GIP incretin response",
    "DIAAS-graded amino acid bioavailability"
  ],
  "target": [
    "Skeletal muscle protein synthesis",
    "Incretin axis",
    "Satiety hormones"
  ],
  "use_case": [
    "muscle protein synthesis",
    "sarcopenia prevention",
    "GLP-1 companion",
    "weight management"
  ],
  "body_system": [
    "MUSCULO",
    "METABOLISM",
    "ENDO"
  ],
  "evidence_tier": "A",
  "evidence_anchor_pmid_count": 78,
  "evidence_long_form_url": "https://asxan.ai/blog/protein-source-decision-tree-whey-vs-yeast-focus/",
  "dosage_range": "1.2-1.6 g/kg/day protein intake target (Morton 2018 PMID 28698222 meta); 20-40 g/serving optimal MPS (Macnaughton 2016 PMID 27511985)",
  "safety_notes": "Healthy-kidney rebuttal (Devries 2018 meta · PMID 30383278); soy isoflavone hormonal effects rebuttal (Hamilton-Reeves 2010); acid-ash bone hypothesis debunked (Fenton 2009)",
  "regulatory": {
    "fda": "GRAS for food/supplement protein",
    "efsa": "Authorized claim for protein contribution to muscle mass + bone health",
    "anvisa": "RDC 243/2018 · IN 28/2018 protein authorized claims"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/protein/",
  "related_goal_slugs": [
    "athletic-performance",
    "glp-1-companion",
    "weight-management",
    "healthy-aging"
  ],
  "related_lifestyle_slugs": [
    "athletic-performance",
    "senior-60-plus",
    "glp-1-companion",
    "plant-based"
  ],
  "last_evidence_review": "2026-05-24",
  "schema_version": "nc-public-v0.1"
}