🇺🇸 FDA
GRAS for S. cerevisiae as food ingredient (21 CFR 184.1983) · protein isolate forms covered under DSHEA dietary supplement framework
Yeast Protein (S. cerevisiae whole-cell protein isolate)
Also known as: Saccharomyces cerevisiae protein · Brewer's yeast protein · Nutritional yeast protein isolate · Single-cell protein (yeast)
Mechanism of action
- Complete EAA profile (PDCAAS ~0.91) supplies leucine for mTORC1 activation
- Post-exercise muscle protein synthesis stimulation
- Plant/microbial-origin anabolic substrate
Molecular + tissue targets
- Skeletal muscle mTORC1
- EAA pool (leucine threshold ~2.5-3 g)
- Whole-body nitrogen balance
Dosage range
20-40 g/serving post-exercise (Jäger 2017 ISSN position stand PMID 28642676 · 0.4 g/kg/meal · ~2.5 g leucine threshold) · Berrazaga 2019 PMID 31394788 plant vs animal anabolic differential review · van Vliet 2015 PMID 26224750 J Nutr leucine + plant protein anabolic gap
Safety notes
Generally well-tolerated in healthy adults · purine content elevated (caution in hyperuricemia/gout) · IgE-mediated yeast allergy rare but documented · pregnancy/lactation data limited for isolate form · Direct-evidence note: the single direct yeast-protein human RCT (AnPro DB-RCT) is published as DOI 10.12691/jfnr-12-5-9 and is not PubMed-indexed; PubMed-indexed support to date is from mycoprotein-analog and yeast β-glucan studies, not the protein isolate itself
Cross-market regulatory status
🇪🇺 EFSA
No yeast-protein-specific EU authorized health claim under Reg 432/2012; the generic protein authorized claims (Protein contributes to growth / maintenance of muscle mass / maintenance of normal bones) apply when the source-of-protein threshold is met (≥ 12% of energy value of the food provided by protein). Novel-food evaluation pending for specific isolate processes (Reg 2015/2283 case-by-case)
🇧🇷 ANVISA
RDC 243/2018 dietary supplement framework · the generic protein IN 28/2018 Anexo V alegação funcional verbatim "As proteínas auxiliam na formação dos músculos e ossos." applies when yeast-protein content meets Anexo III ≥ 8,4 g/dia adults and the Anexo VII essential amino acid profile is satisfied (yeast protein PDCAAS ~0.91 with complete EAA profile generally qualifies)
Authorized claims · verbatim (4)
Direct quotes from each jurisdiction's framework · never paraphrased · with framework reference and conditions of use.
🇪🇺 EFSA · 3 claims
Reg 432/2012
Protein contributes to a growth in muscle mass
Conditions: The claim may be used only for food which is at least a source of protein as referred to in the claim SOURCE OF PROTEIN as listed in the Annex to Regulation (EC) No 1924/2006 (≥ 12% of energy value of the food provided by protein). Applies to yeast protein as a generic nutrient-level protein claim.
Authorized 2012
Reg 432/2012
Protein contributes to the maintenance of muscle mass
Conditions: The claim may be used only for food which is at least a source of protein as referred to in the claim SOURCE OF PROTEIN as listed in the Annex to Regulation (EC) No 1924/2006 (≥ 12% of energy value of the food provided by protein). Applies to yeast protein as a generic nutrient-level protein claim.
Authorized 2012
Reg 432/2012
Protein contributes to the maintenance of normal bones
Conditions: The claim may be used only for food which is at least a source of protein as referred to in the claim SOURCE OF PROTEIN as listed in the Annex to Regulation (EC) No 1924/2006 (≥ 12% of energy value of the food provided by protein). Applies to yeast protein as a generic nutrient-level protein claim.
Authorized 2012
🇧🇷 ANVISA · 1 claim
IN 28/2018 Anexo V alegação funcional
As proteínas auxiliam na formação dos músculos e ossos.
Conditions: IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares que atendam aos valores mínimos do Anexo III (≥ 8,4 g/dia para adultos ≥ 19 anos) e ao perfil de aminoácidos essenciais do Anexo VII (proteína de referência). Aplica-se à yeast protein como proteína nutriente genérica.
Authorized 2018
Common use cases
- post-exercise recovery
- plant-forward protein supplementation
- sarcopenia mitigation (adjunct)
Cross-reference
Health goals: athletic performance longevity stack
Lifestyles: athletic performance senior 60 plus plant based
Full dossier: /ingredients/yeast-protein/
Machine-readable JSON: /api/nc/yeast-protein.json