{
  "authorized_claims": [
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to a growth in muscle mass",
      "authorization_date": "2012",
      "conditions": "The claim may be used only for food which is at least a source of protein as referred to in the claim SOURCE OF PROTEIN as listed in the Annex to Regulation (EC) No 1924/2006 (≥ 12% of energy value of the food provided by protein). Applies to yeast protein as a generic nutrient-level protein claim."
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to the maintenance of muscle mass",
      "authorization_date": "2012",
      "conditions": "The claim may be used only for food which is at least a source of protein as referred to in the claim SOURCE OF PROTEIN as listed in the Annex to Regulation (EC) No 1924/2006 (≥ 12% of energy value of the food provided by protein). Applies to yeast protein as a generic nutrient-level protein claim."
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to the maintenance of normal bones",
      "authorization_date": "2012",
      "conditions": "The claim may be used only for food which is at least a source of protein as referred to in the claim SOURCE OF PROTEIN as listed in the Annex to Regulation (EC) No 1924/2006 (≥ 12% of energy value of the food provided by protein). Applies to yeast protein as a generic nutrient-level protein claim."
    },
    {
      "market": "ANVISA",
      "framework_reference": "IN 28/2018 Anexo V alegação funcional",
      "claim_verbatim": "As proteínas auxiliam na formação dos músculos e ossos.",
      "authorization_date": "2018",
      "conditions": "IN 28/2018 Anexo V: alegação restrita aos suplementos alimentares que atendam aos valores mínimos do Anexo III (≥ 8,4 g/dia para adultos ≥ 19 anos) e ao perfil de aminoácidos essenciais do Anexo VII (proteína de referência). Aplica-se à yeast protein como proteína nutriente genérica."
    }
  ],
  "slug": "yeast-protein",
  "name": "Yeast Protein (S. cerevisiae whole-cell protein isolate)",
  "alternate_names": [
    "Saccharomyces cerevisiae protein",
    "Brewer's yeast protein",
    "Nutritional yeast protein isolate",
    "Single-cell protein (yeast)"
  ],
  "mechanism": [
    "Complete EAA profile (PDCAAS ~0.91) supplies leucine for mTORC1 activation",
    "Post-exercise muscle protein synthesis stimulation",
    "Plant/microbial-origin anabolic substrate"
  ],
  "target": [
    "Skeletal muscle mTORC1",
    "EAA pool (leucine threshold ~2.5-3 g)",
    "Whole-body nitrogen balance"
  ],
  "use_case": [
    "post-exercise recovery",
    "plant-forward protein supplementation",
    "sarcopenia mitigation (adjunct)"
  ],
  "body_system": [
    "MUSCLE",
    "METABOLISM",
    "IMMUNE"
  ],
  "evidence_tier": "C",
  "evidence_anchor_pmid_count": 11,
  "evidence_breakdown": {
    "meta_sr": 0,
    "human_rct": 0,
    "total_indexed": 11
  },
  "dosage_range": "20-40 g/serving post-exercise (Jäger 2017 ISSN position stand PMID 28642676 · 0.4 g/kg/meal · ~2.5 g leucine threshold) · Berrazaga 2019 PMID 31394788 plant vs animal anabolic differential review · van Vliet 2015 PMID 26224750 J Nutr leucine + plant protein anabolic gap",
  "safety_notes": "Generally well-tolerated in healthy adults · purine content elevated (caution in hyperuricemia/gout) · IgE-mediated yeast allergy rare but documented · pregnancy/lactation data limited for isolate form · Direct-evidence note: the single direct yeast-protein human RCT (AnPro DB-RCT) is published as DOI 10.12691/jfnr-12-5-9 and is not PubMed-indexed; PubMed-indexed support to date is from mycoprotein-analog and yeast β-glucan studies, not the protein isolate itself",
  "regulatory": {
    "fda": "GRAS for S. cerevisiae as food ingredient (21 CFR 184.1983) · protein isolate forms covered under DSHEA dietary supplement framework",
    "efsa": "No yeast-protein-specific EU authorized health claim under Reg 432/2012; the generic protein authorized claims (Protein contributes to growth / maintenance of muscle mass / maintenance of normal bones) apply when the source-of-protein threshold is met (≥ 12% of energy value of the food provided by protein). Novel-food evaluation pending for specific isolate processes (Reg 2015/2283 case-by-case)",
    "anvisa": "RDC 243/2018 dietary supplement framework · the generic protein IN 28/2018 Anexo V alegação funcional verbatim \"As proteínas auxiliam na formação dos músculos e ossos.\" applies when yeast-protein content meets Anexo III ≥ 8,4 g/dia adults and the Anexo VII essential amino acid profile is satisfied (yeast protein PDCAAS ~0.91 with complete EAA profile generally qualifies)"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/yeast-protein/",
  "related_goal_slugs": [
    "athletic-performance",
    "longevity-stack"
  ],
  "related_lifestyle_slugs": [
    "athletic-performance",
    "senior-60-plus",
    "plant-based"
  ],
  "last_evidence_review": "2026-06-03",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-03",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}