Ubiquinol
Evidence Fact Sheet
Reduced CoQ10
Ubiquinol (Reduced CoQ10) · evidence reference and FAQ. Educational only.
Also known as: Reduced Coenzyme Q10 · Ubiquinol-10 · QH · Kaneka QH
Mechanism of Action
Already-reduced (active antioxidant) form of CoQ10 — no cellular reduction step required · Mitochondrial electron transport chain electron carrier · Lipid-phase antioxidant (regenerates the vitamin E radical) · Statin-induced CoQ10 depletion rescue
Body systems: Cardiovascular · Mitochondrial & Cellular Energy · METABOLISM
Dosage (research context · not a recommendation)
100-200 mg/day ubiquinol (both doses improved flow-mediated dilation in a dyslipidemia RCT · PMID 32326664); doses to 1500 mg/day tolerated in MSA trials; take with fat
Regulatory Status · 4 Markets
- US · FDA
- Self-affirmed GRAS (Kaneka Ubiquinol / KanekaQH) · DSHEA dietary supplement; structure/function claims permitted
- EU · EFSA
- No authorized health claim (same status as CoQ10, claims rejected 2010); permitted as food supplement
- CN · China
- China SAMR: ubiquinol (reduced CoQ10) follows the ubidecarenone (CoQ10) Health Food Raw Material framework (2021 filing route · immune-enhancement + antioxidant functions); general food cannot make claims.
- BR · ANVISA
- RDC 243/2018 dietary supplement · IN 28/2018 alegação funcional not authorized
Safety
Generally well tolerated (Kaneka Ubiquinol self-affirmed GRAS · non-GMO yeast fermentation); theoretical warfarin interaction (quinone structure); note: the bioavailability advantage over ubiquinone is reported but inconsistent across crossover studies
Related
Goals: heart-health · longevity-stack · athletic-performance
Lifestyles: senior-60-plus · high-stress
Last evidence review: 2026-07-11