{
  "authorized_claims": [
    {
      "market": "FDA",
      "framework_reference": "21 CFR 101.72 Authorized Health Claim (SSA standard · docket 2008Q-0317 final rule)",
      "claim_verbatim": "Adequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis.",
      "authorization_date": "2008",
      "conditions": "Significant Scientific Agreement (SSA) standard · authorized health claim (not qualified)"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Vitamin D contributes to the maintenance of normal bones.",
      "authorization_date": "2012"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Vitamin D contributes to the maintenance of normal muscle function.",
      "authorization_date": "2012"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Vitamin D contributes to the normal function of the immune system.",
      "authorization_date": "2012"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Vitamin D contributes to normal absorption/utilisation of calcium and phosphorus.",
      "authorization_date": "2012"
    },
    {
      "market": "ANVISA",
      "framework_reference": "IN 28/2018 alegações funcionais",
      "claim_verbatim": "A vitamina D auxilia na absorção e fixação do cálcio nos ossos e dentes, no funcionamento normal dos músculos e do sistema imune.",
      "authorization_date": "2018"
    }
  ],
  "slug": "vitamin-d3",
  "name": "Vitamin D3 (Cholecalciferol)",
  "alternate_names": [
    "Cholecalciferol",
    "25-hydroxyvitamin D3 precursor"
  ],
  "mechanism": [
    "VDR (vitamin D receptor) ligand",
    "Calcium/phosphate homeostasis",
    "Immune modulation",
    "Antimicrobial peptide induction (cathelicidin)"
  ],
  "target": [
    "VDR transcription factor",
    "Calcium-phosphate axis",
    "Innate immunity"
  ],
  "use_case": [
    "bone health",
    "skeletal mineralization",
    "immune support adequacy",
    "fall prevention older adults"
  ],
  "body_system": [
    "MUSCULO",
    "IMMUNE",
    "ENDO",
    "METABOLISM"
  ],
  "evidence_tier": "A",
  "evidence_anchor_pmid_count": 37,
  "dosage_range": "600-2000 IU/day general adult; up to 4000 IU/day UL (FNB); test-and-treat for deficiency (25(OH)D < 20 ng/mL)",
  "safety_notes": "Hypercalcemia risk at sustained > 10,000 IU/day; VITAL primary endpoint negative (cardiovascular + cancer primary prevention) — secondary endpoints + subgroups disclose honestly",
  "regulatory": {
    "fda": "GRAS · qualified health claim (calcium + vitamin D and osteoporosis · docket 2008Q-0317)",
    "efsa": "Authorized claims for bone, muscle, immune, calcium absorption",
    "anvisa": "RDC 243/2018 · IN 28/2018 authorized claims (bone, muscle, immune)"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/vitamin-d3/",
  "related_goal_slugs": [
    "joint-bone",
    "menopause-support",
    "inflammation-relief"
  ],
  "related_lifestyle_slugs": [
    "pregnancy",
    "menopause",
    "senior-60-plus",
    "plant-based"
  ],
  "last_evidence_review": "2026-05-23",
  "schema_version": "nc-public-v0.1"
}