{
  "slug": "turkey-tail",
  "name": "Turkey Tail (Trametes versicolor)",
  "alternate_names": [
    "Coriolus versicolor",
    "Yunzhi",
    "PSK (Polysaccharide-K)",
    "PSP (Polysaccharopeptide)",
    "Trametes versicolor"
  ],
  "mechanism": [
    "PSK/PSP β-glucan polysaccharides reported to activate NK-cell and T-cell responses in preclinical models",
    "TLR2-mediated innate-immune signaling (mechanistic)",
    "Prebiotic-type gut-microbiota modulation (small human / preclinical signal)",
    "Antioxidant phenolic constituents (in-vitro assays)"
  ],
  "target": [
    "NK cells",
    "T cells",
    "TLR2",
    "Gut microbiota"
  ],
  "use_case": [
    "immune-modulation surrogate markers (research-context)",
    "gut-microbiota balance (research-context · preliminary)"
  ],
  "body_system": [
    "IMMUNE",
    "GUT"
  ],
  "evidence_tier": "C",
  "evidence_anchor_pmid_count": 3,
  "dosage_range": "Fruiting-body powder or standardized polysaccharide extract 1–3 g/day in research (educational reference, not a dosing recommendation)",
  "safety_notes": "Generally well tolerated in studies; rare mild GI discomfort. Insufficient safety data in immunosuppressed individuals — medical guidance advised. Theoretical interaction with immunosuppressants/chemotherapy — consult a healthcare provider. Pregnancy/lactation data limited. Educational, not medical advice.",
  "regulatory": {
    "fda": "DSHEA lawful dietary-supplement ingredient (functional-mushroom category); structure/function claims only · NO FDA-authorized health claim. PSK (Krestin) is an approved PRESCRIPTION oncology drug in Japan — that approval does NOT transfer to supplements; 'anti-cancer' claims absolutely forbidden.",
    "efsa": "Permitted as a food-supplement ingredient; 0 EFSA-authorized health claims for Trametes versicolor.",
    "anvisa": "NOT specifically listed — no dedicated ANVISA mushroom-polysaccharide entry; new-ingredient pathway assessment required; market access uncertain (⚠️)."
  },
  "authorized_claims": [],
  "ingredient_hub_url": "https://asxan.ai/ingredients/turkey-tail/",
  "related_goal_slugs": [
    "gut-digestion",
    "longevity-stack"
  ],
  "related_lifestyle_slugs": [
    "senior-60-plus"
  ],
  "last_evidence_review": "2026-06-13",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-13",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}