{
  "authorized_claims": [
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Vitamin E contributes to the protection of cells from oxidative stress.",
      "authorization_date": "2012",
      "conditions": "Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a \"source of vitamin E\" — applies to tocotrienols within total α-tocopherol equivalents calculation"
    }
  ],
  "slug": "tocotrienols",
  "name": "Tocotrienols (Palm Tocotrienol-Rich Fraction · Annatto-Sourced)",
  "alternate_names": [
    "Palm TRF",
    "Annatto tocotrienols",
    "δ-tocotrienol",
    "γ-tocotrienol"
  ],
  "mechanism": [
    "Unsaturated isoprenoid side chain allows wider distribution into membrane lipids than α-tocopherol",
    "HMG-CoA reductase suppression at high doses (cholesterol pathway)",
    "NF-κB and STAT3 modulation in inflammatory contexts"
  ],
  "target": [
    "Lipid profile (modest LDL-C effects)",
    "Oxidative stress markers",
    "Inflammatory cytokines"
  ],
  "use_case": [
    "cellular oxidative stress protection",
    "lipid profile adjunct (modest)",
    "anti-inflammatory adjunct"
  ],
  "body_system": [
    "CELL",
    "CARDIO"
  ],
  "evidence_tier": "B",
  "evidence_anchor_pmid_count": 1,
  "dosage_range": "50-300 mg/day palm tocotrienol-rich fraction (TRF) — 2025 Nutrition Reviews systematic review (PMID 38916919) of 30 RCT (n = 2,646) supports benefits in inflammation and lipid peroxidation but emphasises the need for further standardisation on optimal dose, duration and formulation",
  "safety_notes": "Generally well tolerated at the typical 50-300 mg/day range; uncertain long-term safety at higher doses; potential interaction with statins (mechanism overlap on HMG-CoA reductase) — discuss with clinician for users on lipid-lowering therapy",
  "regulatory": {
    "fda": "GRAS · DSHEA dietary supplement · structure/function claims permitted; not a separately scheduled FDA Daily Value",
    "efsa": "Falls under the Reg 432/2012 vitamin E oxidative-stress claim when calculated within α-tocopherol equivalents; no standalone tocotrienol authorized claim",
    "anvisa": "RDC 243/2018 dietary supplement · IN 28/2018 vitamin E framework applicable when tocotrienol is counted within α-tocopherol equivalents"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/tocotrienols/",
  "related_goal_slugs": [
    "inflammation-relief",
    "heart-health",
    "longevity-stack"
  ],
  "related_lifestyle_slugs": [
    "senior-60-plus"
  ],
  "last_evidence_review": "2026-06-04",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-04",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}