{
  "slug": "spermidine",
  "name": "Spermidine (natural polyamine · wheat-germ extract)",
  "alternate_names": [
    "N-(3-aminopropyl)-1,4-butanediamine",
    "Wheat germ extract (spermidine-standardized)"
  ],
  "mechanism": [
    "Autophagy induction via EP300 acetyltransferase inhibition (research context · preclinical/mechanistic)",
    "eIF5A hypusination supporting mitochondrial function (mechanistic)",
    "Epigenetic modulation of histone acetylation state",
    "Immune-cell (T-cell) differentiation modulation (ex vivo research)"
  ],
  "target": [
    "EP300 acetyltransferase",
    "eIF5A hypusination pathway",
    "mTORC1-linked autophagy machinery",
    "Mitochondria"
  ],
  "use_case": [
    "cognitive / memory markers in older adults (research-context · 2 RCTs, mixed primary-endpoint results)",
    "cellular autophagy biology (mechanistic / preclinical narrative · no human clinical endpoint)",
    "healthy-aging research interest (preclinical/observational · no human longevity RCT)"
  ],
  "body_system": [
    "NEURO",
    "CELL",
    "MITO",
    "IMMUNE"
  ],
  "evidence_tier": "B",
  "evidence_anchor_pmid_count": 3,
  "dosage_range": "1-6 mg/day spermidine in the two cognition RCTs (delivered as spermidine-rich wheat-germ extract, several grams of extract). Educational reference only; not a dosing recommendation. Long-term high-dose human safety data limited.",
  "safety_notes": "Spermidine is a natural dietary polyamine (wheat germ, soy, mushrooms, aged cheese) with a good tolerability profile at food-relevant intakes; the two RCTs (1-6 mg/day for 3-12 months) reported no major safety concerns. High-dose and beyond-12-month human safety data are limited. Wheat-germ-derived extracts are not suitable for people with wheat/gluten sensitivity. Pregnancy/lactation data inadequate. Educational, not medical advice.",
  "regulatory": {
    "fda": "Lawful dietary-supplement ingredient (spermidine / wheat-germ extract standardized to spermidine) under DSHEA; structure/function claims only (e.g. 'cellular renewal support', 'healthy aging support'). NO FDA authorized or qualified health claim for spermidine.",
    "efsa": "Spermidine-rich wheat-germ extract is sold as a food supplement in the EU (a primary spermidine research/market region · Austria TLL/Longevity Labs); NO EFSA-authorized health claim under Reg 432/2012. Synthetic spermidine may face a different (Novel Food) regulatory path than the natural wheat-germ source.",
    "anvisa": "Spermidine's explicit status as a food-supplement ingredient under RDC 243/2018 / IN 28/2018 is to be confirmed (vault flag ⚠️); NO Anexo V alegação funcional for spermidine."
  },
  "authorized_claims": [],
  "ingredient_hub_url": "https://asxan.ai/ingredients/spermidine/",
  "related_goal_slugs": [
    "longevity-stack",
    "cognitive-support"
  ],
  "related_lifestyle_slugs": [
    "senior-60-plus"
  ],
  "last_evidence_review": "2026-06-13",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-13",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}