{
  "authorized_claims": [
    {
      "market": "FDA",
      "framework_reference": "21 CFR 101.82",
      "claim_verbatim": "Diets low in saturated fat and cholesterol that include 25 grams of soy protein a day may reduce the risk of heart disease. One serving of [name of food] provides ___ grams of soy protein.",
      "authorization_date": "1999",
      "conditions": "21 CFR 101.82(c)(2)(i): food must contain at least 6.25 g soy protein per reference amount customarily consumed; (ii) food must meet low fat, low saturated fat, low cholesterol criteria; (iii) the claim applies to soy protein reducing CHD risk via cholesterol reduction · 2017 FDA proposed rule to revoke remains pending"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to a growth in muscle mass.",
      "authorization_date": "2012",
      "conditions": "Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a \"source of protein\" — ≥ 12% of energy value provided by protein"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to the maintenance of muscle mass.",
      "authorization_date": "2012",
      "conditions": "Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a \"source of protein\" — ≥ 12% of energy value provided by protein"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Protein contributes to the maintenance of normal bones.",
      "authorization_date": "2012",
      "conditions": "Reg 1924/2006 art 10(2) + Annex: claim may only be used for food which is at least a \"source of protein\" — ≥ 12% of energy value provided by protein"
    },
    {
      "market": "ANVISA",
      "framework_reference": "IN 28/2018 Anexo V alegação funcional",
      "claim_verbatim": "As proteínas auxiliam na formação dos músculos e ossos.",
      "authorization_date": "2018",
      "conditions": "IN 28/2018 Anexo V: alegação restrita aos suplementos cuja quantidade de proteína e perfil de aminoácidos essenciais atendam os Anexos III + VII"
    }
  ],
  "slug": "soy-protein",
  "name": "Soy Protein (SPC · SPI · Textured Soy Protein)",
  "alternate_names": [
    "Soy protein concentrate",
    "Soy protein isolate",
    "Textured soy protein"
  ],
  "mechanism": [
    "Plant-source complete protein (PDCAAS 1.0) with all essential amino acids",
    "mTORC1 activation via leucine triggering of MPS",
    "Cholesterol-lowering via bile acid binding / hepatic LDL receptor up-regulation at 25 g/day (basis for FDA QHC)"
  ],
  "target": [
    "Skeletal muscle protein synthesis",
    "Serum LDL-C / total cholesterol panel at the 25 g/day threshold",
    "Bone health under the protein authorized claim"
  ],
  "use_case": [
    "plant-based diet protein adequacy",
    "cardiovascular risk reduction (25 g/day cholesterol claim)",
    "muscle maintenance during resistance training"
  ],
  "body_system": [
    "MUSCULO",
    "CARDIO",
    "METABOLISM"
  ],
  "evidence_tier": "B",
  "evidence_anchor_pmid_count": 2,
  "dosage_range": "25 g/day for the FDA QHC cholesterol reduction (21 CFR 101.82); 20-40 g/serving for muscle protein synthesis (Messina 2018 PMID 29722584 IJSNEM meta of 9 RCT n=266 found no significant difference between soy and animal protein on lean body mass or strength gains in resistance training)",
  "safety_notes": "Soy allergy is a contraindication; thyroid medication interaction (separate by at least 4 hours per FDA levothyroxine labelling); phytoestrogen content has a low-to-modest effect on hormonal axes in healthy adults but is not recommended for prepubertal individuals or during pregnancy without clinician guidance",
  "regulatory": {
    "fda": "GRAS · DSHEA dietary supplement · 1 authorized health claim 21 CFR 101.82 (soy protein + CHD risk · 25 g/day) · 2017 FDA proposed rule to revoke / restrict remains pending",
    "efsa": "Authorized protein claims (Reg 432/2012) for muscle mass + bone maintenance available when food source provides ≥ 12% energy from protein",
    "anvisa": "RDC 243/2018 dietary supplement · IN 28/2018 Anexo V alegação funcional verbatim: \"As proteínas auxiliam na formação dos músculos e ossos.\" (Anexo III ≥ 8,4 g/dia adultos ≥ 19 anos · Anexo VII proteína de referência AAE/g)"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/soy-protein/",
  "related_goal_slugs": [
    "athletic-performance",
    "heart-health",
    "menopause-support",
    "weight-management"
  ],
  "related_lifestyle_slugs": [
    "plant-based",
    "athletic-performance",
    "senior-60-plus"
  ],
  "last_evidence_review": "2026-06-04",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-04",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}