{
  "slug": "p5p",
  "name": "Pyridoxal 5'-Phosphate (P5P)",
  "alternate_names": [
    "P5P",
    "PLP",
    "Pyridoxal 5'-Phosphate",
    "Active Vitamin B6"
  ],
  "mechanism": [
    "Biologically active coenzyme form of vitamin B6, usable without hepatic conversion",
    "Cofactor for cystathionine beta-synthase (CBS) in the homocysteine transsulfuration pathway",
    "Cofactor in amino acid and neurotransmitter metabolism (DOPA decarboxylase, GABA synthesis)",
    "Essential coenzyme for over 100 enzymatic reactions"
  ],
  "target": [
    "Homocysteine",
    "Cystathionine beta-synthase (CBS)",
    "DOPA decarboxylase",
    "GABA-synthesizing enzymes (glutamate decarboxylase)"
  ],
  "use_case": [
    "Homocysteine metabolism (research context, combination formula only)",
    "Vitamin B6 nutritional supplementation / active B6 status indicator"
  ],
  "body_system": [
    "CARDIO",
    "NEURO"
  ],
  "evidence_tier": "C",
  "evidence_anchor_pmid_count": 3,
  "dosage_range": "25-100 mg/day (commercial range); homocysteine combination-formula research used 50-100 mg P5P over 8-12 weeks. UL ~100 mg/day B6-equivalent (IOM).",
  "safety_notes": "Generally well tolerated as the natural active form of vitamin B6. Upper Limit ~100 mg/day B6-equivalent (IOM). Long-term very high doses (>200 mg/day) of vitamin B6 have been associated with peripheral neuropathy (risk is primarily linked to pyridoxine; P5P is considered lower risk, but the UL still applies globally as a red line). China NMPA status is unconfirmed: GB 14880 permits pyridoxine hydrochloride as a B6 fortifier, but whether the P5P form is on the permitted list requires verification.",
  "regulatory": {
    "fda": "Legal dietary supplement ingredient under DSHEA; recognized active form of vitamin B6; eligible for structure/function claims.",
    "efsa": "Pyridoxal 5'-phosphate is an authorized source of vitamin B6 under Directive 2002/46/EC Annex II; EFSA authorized vitamin B6 Article 13.1 health claims apply when the source qualifies as a vitamin B6 contribution.",
    "anvisa": "Permitted as a food supplement ingredient (vitamin B6 form)."
  },
  "authorized_claims": [],
  "ingredient_hub_url": "https://asxan.ai/ingredients/p5p/",
  "related_goal_slugs": [
    "cognitive-support"
  ],
  "related_lifestyle_slugs": [
    "senior-60-plus"
  ],
  "last_evidence_review": "2026-06-13",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-13",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}