{
  "slug": "nmnh",
  "name": "NMNH (Reduced β-NMN · Reduced Nicotinamide Mononucleotide)",
  "alternate_names": [
    "Reduced NMN",
    "β-NMNH",
    "Dihydro-NMN"
  ],
  "mechanism": [
    "Direct NADH pool elevation (preclinical mouse)",
    "Mitochondrial absorption hypothetical",
    "NMNAT-independent NAD+ enhancement (Liu 2021 preclinical)"
  ],
  "target": [
    "NAD+ pool (reduced form)",
    "NMNAT enzymes (preclinical)",
    "Mitochondria"
  ],
  "use_case": [
    "NAD+ enhancement (preclinical mouse · 0 human RCT)",
    "experimental NAD+ precursor"
  ],
  "body_system": [
    "MITO",
    "METABOLISM"
  ],
  "evidence_tier": "C",
  "evidence_anchor_pmid_count": 1,
  "evidence_long_form_url": "https://asxan.ai/blog/reduced-nadh-vs-nmnh-evidence/",
  "dosage_range": "No established human dosing · supplement market 100-300 mg/day (unsupported · Liu 2021 PMID 33793246 mouse 13.6 mg/kg IP only)",
  "safety_notes": "NO human RCT · Liu 2021 PMID 33793246 mouse 4-week IP 13.6 mg/kg/day · \"better than NMN\" marketing framing premature · cell-cycle arrest + glycolysis suppression observed in vitro (mechanism caution)",
  "regulatory": {
    "fda": "NOT GRAS · no NDIN filed · status pending",
    "efsa": "Novel Food required · no authorization",
    "anvisa": "IN 28/2018 GE registration required · no specific framework"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/nmnh/",
  "related_goal_slugs": [
    "longevity-stack"
  ],
  "related_lifestyle_slugs": [],
  "last_evidence_review": "2026-06-02",
  "schema_version": "nc-public-v0.2",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-06-02",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}