{
  "slug": "l-theanine",
  "name": "L-Theanine (γ-glutamylethylamide · tea-derived amino acid)",
  "alternate_names": [
    "Theanine",
    "γ-Glutamylethylamide",
    "Suntheanine (registered)"
  ],
  "mechanism": [
    "α-wave EEG activity promotion (relaxed alertness)",
    "Glutamate receptor partial antagonism",
    "GABA + dopamine + serotonin modulation",
    "Caffeine synergy (smoothed stimulation curve)"
  ],
  "target": [
    "CNS GABAergic + glutamatergic systems",
    "Stress-axis (HPA)",
    "Cognitive arousal"
  ],
  "use_case": [
    "stress reduction (research context)",
    "sleep quality support",
    "attention/focus (caffeine co-supplementation)"
  ],
  "body_system": [
    "CNS",
    "IMMUNE"
  ],
  "evidence_tier": "B",
  "evidence_anchor_pmid_count": 24,
  "dosage_range": "100-400 mg/day; 200 mg most common acute-stress RCT dose; 200 mg + 100 mg caffeine for attention/focus",
  "safety_notes": "Generally well tolerated (GRAS in tea food matrix); no notable interactions; pregnancy data limited",
  "regulatory": {
    "fda": "GRAS (Suntheanine GRN 209) · DSHEA dietary supplement",
    "efsa": "Authorized as food supplement; no health claim",
    "anvisa": "RDC 243/2018 dietary supplement · IN 28/2018 alegação funcional not specifically authorized"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/l-theanine/",
  "related_goal_slugs": [
    "cognitive-support",
    "inflammation-relief"
  ],
  "related_lifestyle_slugs": [
    "high-stress",
    "high-stress",
    "high-stress"
  ],
  "last_evidence_review": "2026-05-29",
  "schema_version": "nc-public-v0.1",
  "api_version": "nc-public-v0.3",
  "_meta": {
    "last_evidence_review": "2026-05-29",
    "ip_axes_disclosed": {
      "public_axes": [
        "mechanism",
        "target",
        "use_case",
        "body_system",
        "evidence_tier",
        "dosage_range",
        "safety_notes",
        "regulatory",
        "authorized_claims"
      ],
      "ip_axes_not_exposed": [
        "proprietary_formula_ratios",
        "clinical_protocol_internals",
        "rnd_pipeline_compounds",
        "supplier_specific_grade_specifications",
        "unpublished_endpoint_data"
      ],
      "rationale": "asxan.ai surfaces the educational, evidence-tier-disclosed slice. Formula composition, clinical-protocol internals, and RnD pipeline data are intentionally outside this public surface."
    }
  }
}