{
  "slug": "fish-oil",
  "name": "Fish Oil (EPA + DHA · marine)",
  "alternate_names": [
    "Marine omega-3",
    "EPA+DHA fish oil",
    "Long-chain omega-3"
  ],
  "mechanism": [
    "EPA → SPM biosynthesis (Resolvins/Protectins/Maresins)",
    "DHA → brain/retinal membrane integration",
    "Arachidonic acid competition"
  ],
  "target": [
    "Eicosanoid balance",
    "Brain phospholipid composition",
    "Cardiovascular event endpoints"
  ],
  "use_case": [
    "cardiovascular prevention (high-risk)",
    "inflammation markers",
    "cognitive maintenance"
  ],
  "body_system": [
    "CARDIO",
    "CNS",
    "IMMUNE"
  ],
  "evidence_tier": "A",
  "evidence_anchor_pmid_count": 32,
  "evidence_long_form_url": "https://asxan.ai/blog/omega-3-evidence-history-cardiovascular-and-inflammation/",
  "dosage_range": "EPA+DHA 250-500 mg/day general; REDUCE-IT 4g/day pure EPA prescription for high-risk CVD",
  "safety_notes": "Atrial fibrillation risk at sustained high-dose mixed EPA+DHA (STRENGTH 2020 PMID 33190147); bleeding theoretical with anticoagulants",
  "regulatory": {
    "fda": "GRAS · qualified health claim docket 2003Q-0401 (CHD); Vascepa (icosapent ethyl) Rx for hypertriglyceridemia",
    "efsa": "Authorized claims for EPA+DHA cardiovascular",
    "anvisa": "RDC 243/2018 · IN 28/2018 EPA+DHA authorized claims"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/fish-oil/",
  "related_goal_slugs": [
    "heart-health",
    "cognitive-support",
    "inflammation-relief"
  ],
  "related_lifestyle_slugs": [
    "senior-60-plus",
    "pregnancy"
  ],
  "last_evidence_review": "2026-05-24",
  "schema_version": "nc-public-v0.1"
}