{
  "authorized_claims": [
    {
      "market": "FDA",
      "framework_reference": "21 CFR 101.81 Authorized Health Claim",
      "claim_verbatim": "Soluble fiber from oats, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. A serving of [name of food] supplies [x] grams of the [necessary daily dietary intake of] beta-glucan soluble fiber from oats necessary per day to have this effect.",
      "authorization_date": "1997",
      "conditions": "≥ 3 g/day β-glucan from whole oats or oat bran"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Oat beta-glucan has been shown to lower/reduce blood cholesterol. High cholesterol is a risk factor in the development of coronary heart disease.",
      "authorization_date": "2012",
      "conditions": "≥ 3 g/day oat β-glucan"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Barley beta-glucan has been shown to lower/reduce blood cholesterol.",
      "authorization_date": "2012",
      "conditions": "≥ 3 g/day barley β-glucan"
    },
    {
      "market": "EFSA",
      "framework_reference": "Reg 432/2012",
      "claim_verbatim": "Beta-glucans contribute to the maintenance of normal blood cholesterol levels.",
      "authorization_date": "2012",
      "conditions": "≥ 1 g/day β-glucan from oats/barley"
    },
    {
      "market": "ANVISA",
      "framework_reference": "IN 28/2018 alegação funcional",
      "claim_verbatim": "A betaglucana (fibra alimentar) auxilia na redução da absorção de colesterol. Seu consumo deve estar associado a uma alimentação equilibrada e hábitos de vida saudáveis.",
      "authorization_date": "2018",
      "conditions": "≥ 3 g/dia de betaglucana de aveia"
    }
  ],
  "slug": "beta-glucan",
  "name": "Beta-Glucan (β-glucan · cereal + yeast variants)",
  "alternate_names": [
    "β-1,3-glucan",
    "(1,3/1,6)-β-D-glucan",
    "Oat β-glucan",
    "Yeast β-glucan"
  ],
  "mechanism": [
    "Cereal: bile acid binding · cholesterol-lowering",
    "Yeast: Dectin-1 receptor immune training · AHCC pathway"
  ],
  "target": [
    "LDL cholesterol (cereal)",
    "Innate immune training (yeast)",
    "Gut microbiome"
  ],
  "use_case": [
    "cholesterol management (cereal β-glucan)",
    "immune support (yeast β-glucan · emerging)"
  ],
  "body_system": [
    "CARDIO",
    "IMMUNE",
    "GUT"
  ],
  "evidence_tier": "A",
  "evidence_anchor_pmid_count": 31,
  "dosage_range": "Cereal: ≥ 3 g/day for cholesterol effect (FDA + EFSA + ANVISA triple-authorized); Yeast: 250-500 mg/day in emerging immune RCTs",
  "safety_notes": "Generally well tolerated; cereal β-glucan negative trial (Ibrügger 2013) disclosed; yeast β-glucan long-term data limited",
  "regulatory": {
    "fda": "Authorized health claim (oat β-glucan + CHD · 21 CFR 101.81)",
    "efsa": "Authorized claim (oat + barley β-glucan + cholesterol maintenance)",
    "anvisa": "RDC 243/2018 · IN 28/2018 oat β-glucan cholesterol claim"
  },
  "ingredient_hub_url": "https://asxan.ai/ingredients/beta-glucan/",
  "related_goal_slugs": [
    "heart-health",
    "gut-digestion"
  ],
  "related_lifestyle_slugs": [
    "senior-60-plus"
  ],
  "last_evidence_review": "2026-05-24",
  "schema_version": "nc-public-v0.1"
}